28
Olive oil quality matters — how to avoid fraud
Most "extra virgin" olive oil in supermarkets fails to meet EVOO standards when independently tested. Since olive oil is a cornerstone of longevity diets, we …
14
Telomere length testing — useful or a waste of money?
I got my telomere length measured through TeloYears. Results say I'm "average for my age." But I've read that telomere length is highly variable, poorly …
20
Klotho protein and aging — is supplementation possible?
The Klotho longevity gene has been in the news recently. Higher Klotho levels are associated with better cognition, kidney function, and cardiovascular health. A UCSF …
25
Metformin vs berberine for longevity — what does the evidence say?
I keep seeing these two compared in longevity circles. Both activate AMPK, both improve insulin sensitivity. Metformin has the TAME trial coming but berberine has …
15
Senolytics company Oisin Biotechnologies — anyone following their progress?
Oisin has been working on a gene therapy approach to clear senescent cells. Their fusogenix lipid nanoparticle delivery system looks promising in animal models. They're …
22
Cold plunge benefits — real or placebo?
I've been doing 2-minute cold plunges at 50°F (10°C) every morning for 3 months. I feel amazing after each session, but I'm struggling to find …
17
Genetic testing for longevity — which service gives the most useful data?
I want to get genetic testing done with a focus on longevity-relevant variants (APOE, FOXO3, CETP, MTHFR, etc). 23andMe has been declining, Nebula offers whole …
19
Longevity community meetup — Bay Area, March 2026
Organizing an informal meetup for longevity enthusiasts in the SF Bay Area. Planning for mid-March at a venue in South Bay. Topics: sharing N=1 protocols, …
33
Sauna vs cold plunge — which has better evidence for longevity?
The Finnish sauna studies show a strong association between sauna use and reduced all-cause mortality. Meanwhile, cold exposure has less epidemiological data but stronger mechanistic …
63
Zone 2 cardio completely changed my metabolic health
After years of HIIT-only training, I switched to 80% zone 2 / 20% high intensity. In 8 months my resting heart rate dropped from 68 …
16
Has anyone tried the Prolon fasting-mimicking diet?
My doctor recommended Prolon for its autophagy benefits. 5 days of restricted calories with specific macros. It's expensive ($250/cycle) and the food is pretty bland. …
35
Continuous glucose monitors for non-diabetics — overhyped?
I wore a Levels CGM for 2 months. Main finding: my glucose responses are completely normal and boring. Rice spikes me, protein doesn't. Groundbreaking stuff. …
34
Fisetin as a senolytic — protocol and experience
Following the Mayo Clinic dosing protocol: 20mg/kg for 2 consecutive days, repeated monthly. I've done 4 cycles now. Subjectively, I notice reduced joint stiffness for …
52
Bryan Johnson's Blueprint — what's actually worth copying?
Love him or hate him, Johnson has popularized longevity optimization. But his protocol is 100+ interventions. For those of us with normal budgets and schedules, …
38
New Kaeberlein paper on rapamycin in dogs — thoughts?
The Dog Aging Project just published their latest rapamycin results. The treated group showed significantly better cardiac function and owner-reported activity levels. What's interesting is …
https://www.nature.com/articles/example…
40
The case for vitamin D supplementation in longevity
Large meta-analyses keep showing that vitamin D supplementation reduces all-cause mortality by ~6%. The VITAL trial showed reduced cancer mortality. Yet most longevity experts barely …
19
Tongkat ali for testosterone — evidence-based or broscience?
My total T was 420 ng/dL at age 38. After 3 months of tongkat ali (400mg standardized extract), it went up to 510. I also …
31
Resistance training for longevity: minimum effective dose?
I know strength training is crucial for healthspan, but I'm time-constrained. What's the minimum effective dose? I've seen arguments for everything from 2x/week full body …
41
Biological age test comparison: TruAge vs GrimAge vs DunedinPACE
I ran three different epigenetic age tests simultaneously. TruAge said I'm 7 years younger, GrimAge said 3 years younger, and DunedinPACE put my pace of …
18
GlycanAge test results — anyone else tracking glycan age?
Just got my GlycanAge results back: biological age 34 vs chronological age 41. I've been focused on reducing inflammation through diet (Mediterranean + time-restricted eating) …