Recent pandemics, the increasing incidence of cancer and an inversion of the age pyramid towards an older society fuels the need for an in depth understanding of the field of inflammaging and changes in the immune system, in particular of the T cell compartment, which is the most impacted during ageing. Starting from quantitative and qualitative changes that occur in T cells during ageing, this review discusses pathophysiological factors that lead to or accelerate these processes. Furthermore, it highlights emerging strategies aimed at overcoming age-related T-cell dysfunction, with a focus on recent advances in the field. Together, these insights may contribute to a better understanding of how healthy ageing can be promoted through the preservation or rejuvenation of T-cell "youthfulness", which is central for healthy ageing.
Healthy ageing: The struggle for maintaining T cells young.
TL;DR
Recent pandemics, the increasing incidence of cancer and an inversion of the age pyramid towards an older society fuels the need for an in depth understanding of the field of inflammaging and changes in the immune system, in particular of the T cell compartment, which is the most impacted during ageing. Starting from quantitative and qualitative changes that occur in T cells during ageing, this review discusses pathophysiological factors that lead to or accelerate these processes. Furthermore, i
Credibility Assessment
Preliminary — 38/100
Study Design
Rigor of the research methodology
5/20
Sample Size
Whether the study was sufficiently powered
7/20
Peer Review
Review status and journal reputation
10/20
Replication
Has this finding been independently reproduced?
6/20
Transparency
Funding disclosure and data availability
10/20
Overall
Sum of all five dimensions
38/100
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