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Preliminary — 38/100 Other PubMed

Multiomics Analysis: Maternal Valine Intake during Protein Restriction Improves Fetal Intestinal Health in Pigs via IgA Homing.

Journal of agricultural and food chemistry February 15, 2026 Wei Siyong, Pang Shujun, Gu Fang, Gao Kaiguo, Ye Xiangyang, Yang Xuefen, Kong Zhiwei, Li Ya-Ying, Jiang Zongyong, Wang Li
TL;DR

Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation. This study investigated whether valine (Val) supplementation in maternal low-protein diets (LPDs) alleviates offspring developmental deficits via a gut-mammary axis. Maternal LPD impaired offspring growth, jejunal morphology, and barrier integrity while reducing levels of secretory immunoglobulin A (sIgA) and related immune mediators in both piglet jejunum and sow mammary gland.

Why This Matters

Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation.

Credibility Assessment Preliminary — 38/100
Study Design
Rigor of the research methodology
5/20
Sample Size
Whether the study was sufficiently powered
7/20
Peer Review
Review status and journal reputation
10/20
Replication
Has this finding been independently reproduced?
6/20
Transparency
Funding disclosure and data availability
10/20
Overall
Sum of all five dimensions
38/100

Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation. This study investigated whether valine (Val) supplementation in maternal low-protein diets (LPDs) alleviates offspring developmental deficits via a gut-mammary axis. Maternal LPD impaired offspring growth, jejunal morphology, and barrier integrity while reducing levels of secretory immunoglobulin A (sIgA) and related immune mediators in both piglet jejunum and sow mammary gland. LPD suppressed CCL28-mediated sIgA homing to the mammary gland, which was restored by optimal Val supplementation (Val/Lys ratio: 0.88%). Val elevated serum valine metabolites and corrected LPD-induced depletion of beneficial genera in milk and the offspring gut, promoting microbial colonization. Thus, Val regulates sIgA immunity and microbial composition via the lactational axis to enhance the intestinal health of offspring under maternal protein restriction.

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