Diet, exercise, and behavioral interventions
In mice, intermittent fasting triggers the production of a metabolite called β-hydroxybutyrate that signals cells to activate DNA repair and antioxidant defense programs in the hippocampus. These protective effects persisted even after mice resumed normal …
Researchers found that cutting calorie intake by 50% in mice slowed age-related damage to the liver and kidneys, reducing fibrosis, metabolic stress, and cellular senescence markers. The protective effect appeared linked to activation of SIRT1, …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
Researchers found that female fruit flies on very low-cholesterol diets had shorter lifespans and developed leaky gut problems. Interestingly, not all flies showed gut damage before dying, suggesting cholesterol may be essential for maintaining intestinal …
This collection brings together 16 studies from researchers worldwide showing that circadian rhythms—your body's 24-hour internal clock—play a central role in aging and longevity. By understanding how these rhythms break down with age, scientists are …
Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …
OBJECTIVES: Observational studies have consistently shown physical activity associated with lower mortality. Randomized controlled trials to confirm the value of physical activity for lifespan in the general population are challenging to conduct. To address this …
The annual CRN-International symposium, “Food Is Medicine: The Role of Nutrition in Extending Healthspan” sought to address the profound impact of dietary habits on health and healthy lifespan, as judicious nutritional choices can serve as …
BACKGROUND: Sarcopenia, characterized by the progressive age-related decline in skeletal muscle mass, strength, and function, represents a major unmet need in geriatric health. Effective and safe interventions to prevent or ameliorate muscle atrophy are urgently …
The growing demand for minimally processed clean-label foods has intensified interest in natural antimicrobials as alternatives to synthetic preservatives. However, very little is known about the antimicrobial potential of several wild edible plants when incorporated …
A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc.) was associated with reduced epigenetic age—a molecular measure of biological aging. However, this was a pilot …
A Reddit discussion summarizes findings from a Nature Biobank study showing vigorous-intensity exercise provides dramatically greater mortality and disease risk reduction per minute compared to moderate or light activity. The post claims just 9 minutes …
A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5.7 years of age reduction. The post acknowledges important uncertainty: spermidine may simply be a …
A Reddit post discusses a study showing that exercise removes senescent (damaged) cells from muscle tissue, reactivates stem cells, and improves insulin sensitivity in middle-aged adults with obesity. The post frames exercise as a cellular-level …
Layne Norton and Peter Attia dive deep into the lipid science comparing seed oils and lard for cooking, concluding that both ultra-processed fried foods are unhealthy regardless of oil type, and that marketing either as …
A study of over 100,000 UK adults found that five well-known healthy eating patterns—from Mediterranean to plant-based diets—were each associated with 1.5–3 extra years of life by age 45, with benefits holding true regardless of …
When male rats ate 15% fewer calories for just 2 weeks, their brown fat (heat-generating tissue) adapted by storing more fat droplets while maintaining its ability to burn energy and produce heat. These coordinated metabolic …
Lisa Mosconi discusses sex-specific Alzheimer's prevention strategies for midlife women, emphasizing behavioral interventions (exercise, sleep, nutrition, stress management) as the primary prevention tools while highlighting emerging pharmaceutical options like GLP-1 agonists and klotho. The conversation …
Peter Attia and Lane Norton examine whether seed oils pose unique health risks compared to other dietary fats, using a structured 'steelman' approach where Attia presents the strongest case against seed oils while Norton defends …
Dr. Rhonda Patrick presents evidence that vigorous-intensity exercise is the most powerful anti-aging intervention available, reversing 20 years of heart aging in 2 years, with each unit improvement in VO2 max adding ~45 days to …