Diet, exercise, and behavioral interventions
Dental prosthesis failure is often associated with biofilm-mediated infections, yet the combined roles of surface roughness and material chemistry remain underexplored. This observational, retrospective study investigated associations between these factors and biofilm density, pathogen selection, …
Aquatic gel foods, including surimi, minced crustacean products, and algal gels, are important platforms for aquatic protein valorization. However, their production is constrained by uneven thermal gelation, endogenous enzyme-driven deterioration, nutrient loss, additive dependence, and …
Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …
ObjectiveThis systematic review and meta-analysis synthesised the global prevalence of overweight and obesity in people with Down syndrome (DS) across the lifespan, characterised determinants of excess adiposity, and examined associations with adverse cardiometabolic outcomes. MethodsSix …
Researchers found that female fruit flies on very low-cholesterol diets had shorter lifespans and developed leaky gut problems. Interestingly, not all flies showed gut damage before dying, suggesting cholesterol may be essential for maintaining intestinal …
Aging is a time-dependent process characterized by a gradual decline in physiological functions, ultimately leading to increased risk of degenerative diseases, health issues, and death. With the growing number of older people and rising health …
Medium-chain triglycerides (MCTs) have attracted considerable interest in functional foods and nutrition due to their rapid and efficient metabolism. Emerging evidence indicates that MCTs can enhance cerebral energy metabolism, supporting interest in their potential role …
Too much or too less lipid deposition increases mortality, while in contrast, modest lipid deposition during aging is crucial for healthspan. How animals determine the aging state and then promote appropriate lipid deposition for lifespan …
The annual CRN-International symposium, “Food Is Medicine: The Role of Nutrition in Extending Healthspan” sought to address the profound impact of dietary habits on health and healthy lifespan, as judicious nutritional choices can serve as …
Breast cancer is among the leading causes of cancer mortality worldwide, with aging as a major risk factor. Caloric restriction (CR) is a well-established non-pharmaceutical intervention that extends healthspan and delays tumorigenesis, yet the systemic …
In mice, intermittent fasting triggers the production of a metabolite called β-hydroxybutyrate that signals cells to activate DNA repair and antioxidant defense programs in the hippocampus. These protective effects persisted even after mice resumed normal …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
Fibroblast growth factor 21 (FGF21) is a hormone produced mainly in the liver that plays a crucial role in systemic metabolic regulation. Its diverse metabolic functions include promoting glucose uptake in adipocytes, enhancing fat oxidation, …
Glucose oxidase (GOX) is widely recognized for its potential in food preservation, yet its practical application is often limited by insufficient stability and catalytic efficiency under processing conditions. In this study, a GOX from Aspergillus …
In a study of 1,545 Chinese people aged 80+, researchers found that maintaining healthy lifestyle factors reduced death risk by 41% and added nearly 7 years of life—even more than genetic advantages. Importantly, good genes …
Human menopause and the prolonged post-reproductive lifespan (PRLS) are distinctive features of female aging with profound implications for long-term health. Evolutionary theories, such as the Grandmother Hypothesis and other models (e.g., intergenerational reproductive conflict), suggest …
This review examines SIRT1, a protein activated by exercise that helps counteract multiple aging processes across the body. Evidence from animal and human studies shows different exercise types can boost SIRT1 levels in key organs, …
This study evaluated the effects of ozone (O₃) on the population dynamics of aerobic mesophilic microorganisms and the preservation of the physicochemical quality of mushrooms (Lentinula edodes) during storage. Samples of 100 g were treated …
This collection brings together 16 studies from researchers worldwide showing that circadian rhythms—your body's 24-hour internal clock—play a central role in aging and longevity. By understanding how these rhythms break down with age, scientists are …
Caloric restriction (CR) has shown the potential to extend lifespan and reduce cancer risk; however, the mechanisms underlying CR-mediated tumor suppression are not fully understood. Here, we investigate age-dependent CR effects on tumor progression and …