Diet, exercise, and behavioral interventions
BACKGROUND: Sarcopenia, characterized by the progressive age-related decline in skeletal muscle mass, strength, and function, represents a major unmet need in geriatric health. Effective and safe interventions to prevent or ameliorate muscle atrophy are urgently …
Researchers discovered that aging pancreas alpha cells trigger inflammatory immune responses linked to type 2 diabetes. In mice, calorie restriction reversed this inflammation by reducing immune cell recruitment to the pancreas. This suggests a new …
This review examines how anti-aging interventions affect males and females differently, exploring whether sex differences stem from baseline lifespan variations, body composition, metabolism, or hormone/chromosome differences. The authors argue that treating sex as a biological …
Researchers exposed C. elegans worms to odors from the Maillard reaction (the browning that happens when food is cooked) and found it extended lifespan, improved movement, and boosted stress resistance—effects that depended on activating a …
In mice, intermittent fasting triggers the production of a metabolite called β-hydroxybutyrate that signals cells to activate DNA repair and antioxidant defense programs in the hippocampus. These protective effects persisted even after mice resumed normal …
The growing demand for minimally processed clean-label foods has intensified interest in natural antimicrobials as alternatives to synthetic preservatives. However, very little is known about the antimicrobial potential of several wild edible plants when incorporated …
Globally, the growing proportion of older individuals is imposing personal and societal costs. However, interventions that slow aging are possible; for example, dampened nutrient signaling pathway activity in animal models promotes better health later in …
Researchers found that limiting daily eating to either 12 or 8 hours improved health markers in both male and female mice, with the stricter 8-hour window extending male lifespan by 12% but showing no significant …
The annual CRN-International symposium, “Food Is Medicine: The Role of Nutrition in Extending Healthspan” sought to address the profound impact of dietary habits on health and healthy lifespan, as judicious nutritional choices can serve as …
This review examines SIRT1, a protein activated by exercise that helps counteract multiple aging processes across the body. Evidence from animal and human studies shows different exercise types can boost SIRT1 levels in key organs, …
This collection brings together 16 studies from researchers worldwide showing that circadian rhythms—your body's 24-hour internal clock—play a central role in aging and longevity. By understanding how these rhythms break down with age, scientists are …
Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …
Researchers found that female fruit flies on very low-cholesterol diets had shorter lifespans and developed leaky gut problems. Interestingly, not all flies showed gut damage before dying, suggesting cholesterol may be essential for maintaining intestinal …
OBJECTIVES: Observational studies have consistently shown physical activity associated with lower mortality. Randomized controlled trials to confirm the value of physical activity for lifespan in the general population are challenging to conduct. To address this …
In a study of 1,545 Chinese people aged 80+, researchers found that maintaining healthy lifestyle factors reduced death risk by 41% and added nearly 7 years of life—even more than genetic advantages. Importantly, good genes …
Researchers found that cutting calorie intake by 50% in mice slowed age-related damage to the liver and kidneys, reducing fibrosis, metabolic stress, and cellular senescence markers. The protective effect appeared linked to activation of SIRT1, …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
This review argues that combining topical skin treatments (retinoids, peptides, antioxidants) with internal supplements (NAD+ precursors, collagen peptides, polyphenols) can target multiple aging mechanisms simultaneously. While conceptually sound, the paper is a narrative review without …
Researchers discovered that fasting and calorie restriction activate a hormone called ADIOL, which works through a specific molecular pathway to improve healthspan—the years we spend healthy and functional—in worms. While ADIOL doesn't extend lifespan itself, …
Caloric restriction, known to extend lifespan, causes fat to accumulate in bone marrow—but this happens only in certain bones and takes 4 weeks to plateau. The study reveals this bone fat expansion is linked to …