Ginsenoside Rg1 (Rg1), an active compound in Panax ginseng C. A. Meyer (ginseng), has shown potential to ameliorate age-related cell damage and extend lifespan in multiple model organisms. However, the precise molecular mechanisms of its …
BACKGROUND: Autophagy genes are essential for proper uterine function, reproductive physiology, and the maintenance of endometrial atrophy (EA). OBJECTIVE: This study aims to clarify how these genes impact endometrial thickness and their significance in the …
Heterozygous mutations in the Glucocerebrosidase gene (GBA1), encoding the lysosomal hydrolase Beta-glucocerebrosidase (GCase), are a genetic risk factor for Parkinsons disease (PD). To explore the pathophysiological consequences of these mutations, we have used fibroblasts and …
Cellular senescence is an irreversible program of cell-cycle arrest that accumulates with age, contributing to chronic inflammation and various age-related diseases. A key feature of senescence paradigms is mitochondrial dysfunction, which involves not just a …
Escitalopram is one of the most widely prescribed selective serotonin reuptake inhibitors (SSRIs) for treating depression and anxiety disorders in adolescents and pregnant women. While some SSRIs have been reported to extend lifespan, the impact …
Lysosomes containing multilamellar membrane whorls are a hallmark of cellular aging and storage disorders, yet the biogenesis of these structures has remained elusive for decades. Here, we identify a distinct form of endoplasmic reticulum (ER) …
During mitotic growth, Saccharomyces cerevisiae cells age by dividing asymmetrically producing young daughter cells while retaining age-associated damage in the mother cell, which will eventually become senescent. Gametogenesis naturally and completely resets precursor cell lifespan, …
Autophagy is a major intracellular degradative process required for maintaining homeostasis in multicellular organisms. Aberrant autophagy is considered to induce internal environmental disturbance and cell death. Therefore, it is of great significance to explore the …
Pulmonary tuberculosis (TB) exhibits marked spatial heterogeneity, with alveolar pneumonia and organized granulomas frequently coexisting within the same lung. While granulomas have long dominated conceptual models of TB pathogenesis, the immune programs operating within alveolar …
Different types of dietary restriction (DR) have been practiced by humans for religious and medical purposes for millennia, but only during the past three decades has the scientific study of DR at cellular and molecular …
Aspartame (ASP) is a common artificial sweetener used in food and beverages. There is currently significant controversy surrounding the safety of aspartame. However, the molecular mechanisms of aspartame on innate immunity and lifespan remain poorly …
Researchers found that coordinated control of proteasome subunit genes—the cellular recycling machinery—is critical for longevity in C. elegans. When this coordination breaks down, even genetic interventions that normally extend lifespan fail, suggesting proteostasis balance is …
Researchers found that hydrolysates (broken-down proteins) from fava beans and peas both reduced aging signs in C. elegans worms, but through different cellular mechanisms—fava bean via antioxidant effects, pea via heat-stress resistance. This suggests legume …
Researchers identified a protein (CG42795) that, when silenced in neurons, enhances cellular cleanup (autophagy) and extends lifespan in fruit flies. The same mechanism works in human cells, suggesting a new therapeutic target for age-related diseases.
Researchers deleted a gene (Mfn2) controlling mitochondrial structure in endothelial cells (blood vessel linings) and found this triggered a protective stress response that improved metabolism, reduced obesity risk, and slowed aging in mice. The effect …
Researchers found that chaetoglobosin F, a compound from fungi, protected genetically engineered worms from amyloid-beta toxicity by enhancing autophagy (cellular cleanup) and reducing oxidative damage. While promising in this model system, the work is still …
Researchers found that an ethanol extract from Salvia plebeia plant enhanced autophagy (cellular garbage disposal) and reversed senescence markers in cell culture and aged mice, with rosmarinic acid identified as a key active ingredient. The …
Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …
Researchers discovered that a ribonuclease enzyme called RNASEK degrades circular RNA molecules that accumulate with age, and boosting this enzyme extended lifespan in worms and prevented premature aging in human cells and mice. This finding …
Acute-on-chronic liver failure (ACLF) is a severe liver syndrome marked by systemic inflammation and high mortality, often complicated by autophagy impairment and mitochondrial dysfunction. This study investigates atractylenolide I (AT-1), a compound from Atractylodes macrocephala, …