Measures of physiological age distinct from chronological age
Biological ageing begins before birth, with early-life exposures shaping late-life health. These exposures drive health inequities early, yet specific exposures and the composition of the ageing exposome remain largely undefined. This gap may persist as …
Epigenetic clocks estimate biological age from DNA methylation patterns at CpG sites, providing robust predictions of mortality and morbidity risk. "Blue zones"--regions of exceptional longevity--offer a unique opportunity to investigate how biological aging diverges from …
Researchers tested whether an FDA-approved HIV medication (tenofovir alafenamide) could slow aging in healthy people by suppressing harmful retrotransposons. Over 12 weeks, the drug showed measurable reductions in epigenetic aging markers, but this is preliminary …
Aging is accompanied by molecular changes across multiple biological systems that contribute to functional decline and increased disease risk, but the underlying mechanisms and inter-individual variation remain poorly understood. We investigated whether multi-omics integration can …
Background Older age is widely considered a risk factor for post-acute sequelae of SARS-CoV-2 infection (PASC), typically attributed to immunosenescence and inflammaging. However, whether this association reflects intrinsic biological ageing or accumulated comorbidity burden remains …
Researchers created a miniature laboratory system using human stem cells that reproduces aging hallmarks in just 4 days—a process that normally takes decades. This 'aging-on-a-chip' could accelerate testing of anti-aging therapies and reveal how rejuvenation …
BACKGROUND Little is known about whether epigenetic age acceleration (EAA) clocks are capable of predicting exceptional longevity with or without preserved cognitive function. METHODS We examined 5844 women from the Women's Health Initiative Memory Study. …
Ageing biomarkers can predict mortality risk beyond chronological age. Recently, plasma proteins were used to estimate the biological ages of eleven human organs, including the brain, heart, liver, kidneys, and pancreas. Accelerated organ ageing is …
Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …
A small clinical trial found that bezisterim, an experimental anti-inflammatory drug, reduced epigenetic markers of aging and was associated with changes in genes linked to brain inflammation and cognitive decline. However, this is early-stage work …
Background and Objectives: Biological age, reflecting the cumulative molecular and cellular damage such as telomere attrition, epigenetic alterations and mitochondrial dysfunction, may better capture age-related decline and Alzheimer's disease (AD) risk than chronological age. Most …
Researchers created a 'protein aging clock' and found that untreated HIV makes people's proteins look ~6 years older than their actual age. When HIV is treated with antiretroviral therapy, this accelerated aging reverses over time, …
Histone modifications represent an untapped resource for biological age prediction that overcomes limitations of traditional DNA methylation-based epigenetic clocks. Here, we developed and validated histone modification-based epigenetic clocks by systematically analyzing publicly available ChIP-seq datasets …
Researchers analyzed blood chemistry in 213 people over 100 years old and found they have distinctly different metabolic profiles—especially higher bile acids and lower inflammatory markers—compared to younger controls. By identifying these metabolic signatures, they …
This editorial argues that biogerontology has been too focused on extending lifespan (how long we live) without clearly defining what healthspan (how well we live) actually means. The author proposes that healthspan should be understood …
Researchers compared DNA methylation aging clocks across three tissue types (saliva, blood cells, and immune cells) in 91 young adults and found that saliva shows different aging patterns than blood, though blood-based samples are interchangeable …
Researchers used AI to estimate cardiovascular 'biological age' from simple heart ultrasounds in 243 adults. People whose heart appeared older than their calendar age had worse metabolic health markers and were twice as likely to …
Biological age estimators quantify aging-related variation but provide limited insight into organ-specific aging processes. The retina enables non-invasive visualization of microvascular and neural structures and has emerged as a promising modality for biological age prediction. …
Researchers enrolled 209 companion dogs in a 30-month study to identify biomarkers of aging that could make dogs a better translational model for human longevity research. Early findings show consistent age-related changes in blood work, …
Researchers developed Personal-MetaboHealth, a blood-based score that predicts heart disease and mortality risk in middle-aged people, and showed it improves with a 3-month lifestyle intervention. The test could become a practical screening tool for early …