Biological Age — OutliveHub

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

Why Aging Isn't One Problem—It's Many Connected Ones

This explains why no single anti-aging drug works for everyone: aging involves many interconnected systems, not one master switch.

This paper argues that biological aging isn't driven by a single master mechanism, but rather by multiple partially independent processes linked through a network of regulatory hubs. This framework explains why anti-aging treatments typically produce …

Biogerontology

34 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other medRxiv

Disentangling physiological heterogeneity in retinal aging using a deep learning-based biological age framework

Biological age estimators quantify aging-related variation but provide limited insight into organ-specific aging processes. The retina enables non-invasive visualization of microvascular and neural structures and has emerged as a promising modality for biological age prediction. …

medrxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Observational medRxiv

Aging May Be a Spreading Disorder of System-Wide Coordination

If this holds up, we may have a better way to measure your body's aging and spot problems early—by checking how well your organ systems still talk to each other.

Researchers developed a new measurement called DISCO that quantifies how disorganized biological systems become with age, using data from multiple large cohorts. They found that this 'entropy' spreads across organ systems rather than occurring in …

medrxiv (preprint)

37 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Observational medRxiv

The Sleep Sweet Spot: How 6–8 hours connects to biological aging across your whole body

Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …

medrxiv (preprint)

39 Early

Preliminary Biomarkers — Aging clocks and measurement tools Observational medRxiv

Does Body Fat Speed Up Aging? Testing Epigenetic Clocks in Young Filipinos

Extra body fat may age your cells faster, but we need more proof to be sure this matters for real health.

Researchers combined six different epigenetic clocks to create a more robust measure of biological aging and tested whether body fat predicts accelerated aging in young Filipino adults. They found consistent links between higher BMI, waist …

medrxiv (preprint)

35 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other bioRxiv

Microstructural and Biomechanical Determinants of Biological Aging

The pulmonary artery undergoes measurable structural and mechanical deterioration with age, but whether these changes can be integrated into a quantitative normative aging prediction model has not been demonstrated. Using two-photon imaging and paired vascular …

biorxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other medRxiv

Epigenetic Clocks of Biological Aging and Cognitively Healthy Longevity: The Women's Health Initiative Memory Study

BACKGROUND Little is known about whether epigenetic age acceleration (EAA) clocks are capable of predicting exceptional longevity with or without preserved cognitive function. METHODS We examined 5844 women from the Women's Health Initiative Memory Study. …

medrxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other bioRxiv

PFAS exposure is associated with accelerated epigenetic ageing in a wild marine mammal

Chronic contaminant exposure may impose hidden physiological costs long before obvious demographic or health effects become detectable in wildlife populations. Epigenetic clocks quantify biological ageing and may provide sensitive biomarkers of cumulative toxicological stress. Per- …

biorxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Skin aging: mechanisms, evaluation, and rejuvenation.

Skin aging, the most visible and accessible manifestation of organismal aging, reflects systemic physiological decline, compromising barrier integrity, immune defense, and regenerative capacity-functions essential for overall tissue homeostasis and longevity. Understanding why and how the …

The EMBO journal

38 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Universal transcriptomic hallmarks of mammalian ageing and mortality.

Ageing and interventions modulate health and mortality1, yet the underlying molecular mechanisms of this modulation remain unclear. Here we integrate more than 11,000 transcriptomes from more than 25 tissues across 4 mammals (mouse, rat, macaque …

Nature

47 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other bioRxiv

A network approach to DNA methylation clocks

Biological age predicts health and lifespan better than chronological age, but remains difficult to measure. One leading molecular proxy for biological age is DNA methylation, which underlies age predictors known as "clocks". These clocks use …

biorxiv (preprint)

34 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Accelerated epigenetic ageing in congenital heart disease: the AccelerAGE study.

BACKGROUND AND AIMS: Adults with congenital heart disease tend to develop both cardiac and noncardiac age-related comorbidities earlier in life than the general population, suggesting accelerated biological ageing. Epigenetic clocks estimate biological age based on …

European heart journal

38 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other medRxiv

Multimodal Deep Learning Reveals the Modular Genetic Architecture of Cardiovascular Aging

Age is the dominant risk factor for cardiovascular disease, yet individuals of the same chronological age can differ markedly in the organs and biological pathways through which cardiovascular vulnerability emerges. We used deep learning to …

medrxiv (preprint)

39 Early

Preliminary Biomarkers — Aging clocks and measurement tools Observational medRxiv

AI Reads Your Heart's Age to Predict Heart Disease Risk

A simple heart test could help doctors spot who's at highest risk for heart attacks or strokes years before problems start.

Researchers used artificial intelligence to analyze ECGs and calculate a person's cardiac "biological age"—how old their heart appears versus their calendar age. They found that people whose hearts looked older than they actually were had …

medrxiv (preprint)

37 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other medRxiv

Specific epigenetic age acceleration measures are associated with oral health outcomes in U.S. adults

Objectives: Oral health conditions impact a significant proportion of the global population. Chronological age is a known risk factor; however, characterization of epigenetic age remains limited and is expected to provide additional insight into biological …

medrxiv (preprint)

34 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Sleep and aging: The role of DNA methylation.

Although its evolutionary origins remain poorly understood, sleep is a highly conserved physiological process crucial to animal life and widely recognized as a major determinant of human healthspan. Sleep disturbances are a major public health …

Experimental gerontology

44 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Evolution of increased longevity and slowed ageing in a genus of tropical butterfly.

Evolution has given rise to lifespans in extant species ranging from days to centuries. Given that mechanisms of ageing are highly conserved, studying long-lived lineages across the animal kingdom could yield insights relevant for healthy …

Nature communications

47 Early

Promising Biomarkers — Aging clocks and measurement tools Cohort Study PubMed

What Slows (and Speeds) Skin Aging at the DNA Level

Identifies everyday habits and drugs linked to skin aging, offering new targets to test—but doesn't yet prove any slow aging.

Researchers analyzed DNA methylation patterns in 851 people and found 37 lifestyle, health, and drug factors linked to skin aging—some slowing it down, others speeding it up. Compounds like aspirin and dihydromyricetin showed associations with …

Clinical epigenetics

57 Promising

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

The Role of Exercise in Regulating Histone Modifications and Non-coding RNAs in Muscle Aging and Sarcopenia.

Sarcopenia, the progressive loss of skeletal muscle mass and function with age, is a major contributor to frailty and decreased quality of life in older adults. While physical exercise remains the most effective intervention, its …

Biochemical genetics

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

Exploring the exposome and unexplained variance in biological ageing - insights from a longitudinal twin study in adolescence and early adulthood

Biological ageing begins before birth, with early-life exposures shaping late-life health. These exposures drive health inequities early, yet specific exposures and the composition of the ageing exposome remain largely undefined. This gap may persist as …

medrxiv (preprint)

34 Early