Researchers created a 'protein aging clock' and found that untreated HIV makes people's proteins look ~6 years older than their actual age. When HIV is treated with antiretroviral therapy, this accelerated aging reverses over time, …
Researchers analyzed blood chemistry in 213 people over 100 years old and found they have distinctly different metabolic profiles—especially higher bile acids and lower inflammatory markers—compared to younger controls. By identifying these metabolic signatures, they …
BackgroundWhile immunologic aging impacts immune responses to vaccination, consistent biomarkers associated with aging of the immune system and suboptimal serologic response to influenza vaccination have not been well-studied. Identification of readily measurable biomarkers of immunosenescence …
Plasma biomarkers of Alzheimers pathology have been studied in relation to cognitive decline and dementia, but no prior study has examined their associations with longevity or healthspan. In this cohort study of older women (N=2,576), …
Researchers created an AI-powered blood biomarker (SASP Score) that measures senescent cell burden and successfully predicted mortality, dementia, heart attacks, and stroke in large population studies. The score also changed in response to exercise intervention, …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
Researchers developed OMICmAge, a biological age measure combining DNA methylation, proteins, and metabolites that predicts mortality and chronic disease better than existing aging clocks. Tested across ~36,000 people, it could become a scalable clinical tool …
The germinal center (GC) is a specialized structure that ensures the production of high-quality antibodies. Although recent studies have pinpointed the existence of a pre-plasma cell (prePC) population within mouse GC B cells, it remains …
Aging is accompanied by molecular changes across multiple biological systems that contribute to functional decline and increased disease risk, but the underlying mechanisms and inter-individual variation remain poorly understood. We investigated whether multi-omics integration can …
BACKGROUND: People with HIV (PWH) experience chronic inflammation and more age-related comorbidities despite antiretroviral therapy (ART). Classical senescence biomarkers (e.g., SA-βGal, p16INK4a, γH2AX and Bcl-2) and senescence-associated secretory phenotype (SASP) factors such as IL-6 reflect …
Researchers analyzed blood gene activity in nearly 2,500 people from long-lived families and found specific genetic signatures associated with aging and survival—including immune system strength and inflammation control. A machine learning model trained on these …
Researchers developed Personal-MetaboHealth, a blood-based score that predicts heart disease and mortality risk in middle-aged people, and showed it improves with a 3-month lifestyle intervention. The test could become a practical screening tool for early …
Researchers analyzed 70 lab tests from 300,000 pregnancies and found that pregnancy triggers rapid aging in some systems (coagulation, thyroid, muscle) while rejuvenating others (kidney, iron, liver)—opposite to normal aging patterns. These 'rejuvenation' mechanisms could …
Researchers developed an AI model that estimates biological age from retinal photographs and found it correlates strongly with cardiovascular, kidney, and metabolic disease markers in over 30,000 people. This suggests eye imaging could become a …
Researchers identified a liver-derived protein called GPLD1 that transfers exercise's cognitive benefits to the brain by targeting blood vessel dysfunction. In aging and Alzheimer's mouse models, boosting GPLD1 or blocking its downstream target TNAP restored …
This review examines whether infusing young plasma can rejuvenate aging bodies, a concept supported by animal experiments but largely unproven in humans. The authors argue that while preclinical models show promise, current clinical applications of …
BACKGROUND: Platelet-rich plasma (PRP) is used as an adjunctive treatment in various medical fields, including orthopaedics, plastic surgery, dermatology, and wound healing. However, PRP application in reproductive medicine, particularly for fertility restoration, remains controversial, specifically …
Therapeutic proteins are central to modern pharmacotherapy, yet their clinical utility is often constrained by short plasma half-life and immunogenicity. Six major half-life extension platforms-PEGylation, hydrophilic polypeptide (XTEN/PAS) fusion, glycoengineering, Fc domain-based strategies, human serum …
This study reveals that a key growth factor called IGF-1 is essential for the rejuvenating effects of young blood on aging brains. When old mice shared circulation with young mice, their brain blood vessels improved—but …
Researchers used AI to estimate cardiovascular 'biological age' from simple heart ultrasounds in 243 adults. People whose heart appeared older than their calendar age had worse metabolic health markers and were twice as likely to …