DNA methylation-based age estimation and age acceleration
Researchers created a 'protein aging clock' and found that untreated HIV makes people's proteins look ~6 years older than their actual age. When HIV is treated with antiretroviral therapy, this accelerated aging reverses over time, …
Ageing biomarkers can predict mortality risk beyond chronological age. Recently, plasma proteins were used to estimate the biological ages of eleven human organs, including the brain, heart, liver, kidneys, and pancreas. Accelerated organ ageing is …
Epigenetic clocks derived from DNA methylation patterns are among the most promising biomarkers of biological aging1-7, as they capture molecular signatures that predict morbidity and mortality beyond chronological age. Although cross-sectional assessments of epigenetic age …
BACKGROUND Little is known about whether epigenetic age acceleration (EAA) clocks are capable of predicting exceptional longevity with or without preserved cognitive function. METHODS We examined 5844 women from the Women's Health Initiative Memory Study. …
Histone modifications represent an untapped resource for biological age prediction that overcomes limitations of traditional DNA methylation-based epigenetic clocks. Here, we developed and validated histone modification-based epigenetic clocks by systematically analyzing publicly available ChIP-seq datasets …
BackgroundWhile immunologic aging impacts immune responses to vaccination, consistent biomarkers associated with aging of the immune system and suboptimal serologic response to influenza vaccination have not been well-studied. Identification of readily measurable biomarkers of immunosenescence …
Researchers compared DNA methylation aging clocks across three tissue types (saliva, blood cells, and immune cells) in 91 young adults and found that saliva shows different aging patterns than blood, though blood-based samples are interchangeable …
Researchers tested 14 different epigenetic clocks (DNA methylation–based age measures) in over 1,000 older adults and found that DunedinPACE, a newer clock, consistently predicted cognitive decline better than older clocks. This suggests DunedinPACE may be …
Researchers analyzed 70 lab tests from 300,000 pregnancies and found that pregnancy triggers rapid aging in some systems (coagulation, thyroid, muscle) while rejuvenating others (kidney, iron, liver)—opposite to normal aging patterns. These 'rejuvenation' mechanisms could …
A small clinical trial found that bezisterim, an experimental anti-inflammatory drug, reduced epigenetic markers of aging and was associated with changes in genes linked to brain inflammation and cognitive decline. However, this is early-stage work …
Researchers developed OMICmAge, a biological age measure combining DNA methylation, proteins, and metabolites that predicts mortality and chronic disease better than existing aging clocks. Tested across ~36,000 people, it could become a scalable clinical tool …
Epigenetic clocks estimate biological age from DNA methylation patterns at CpG sites, providing robust predictions of mortality and morbidity risk. "Blue zones"--regions of exceptional longevity--offer a unique opportunity to investigate how biological aging diverges from …
Biological ageing begins before birth, with early-life exposures shaping late-life health. These exposures drive health inequities early, yet specific exposures and the composition of the ageing exposome remain largely undefined. This gap may persist as …
Age-related circadian disruptions accelerate physiological decline and shorten lifespan. Enhancing circadian amplitude has emerged as a promising strategy for ameliorating age-associated disorders. Here, we show that the circadian-phase-optimized administration of 3'-deoxyadenosine (3dA) strengthens circadian amplitude …
Ambient air pollution has been associated with increased incidence of chronic disease and is estimated to contribute towards 4.2 million early deaths annually. Whilst the health impacts are well described, less is understood about the …
Over the past decade, ageing clocks have become widely adopted as important tools for understanding biological ageing and have been redefining notions of "pro-longevity" lifestyles. However, this work is still at an early stage. Some …
A growing body of evidence supports the role of nutrient sensing and metabolism pathways in regulating ageing rate and healthspan, but the diversity of human lifestyles challenges our ability to identify the mechanisms of this …
A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc.) was associated with reduced epigenetic age—a molecular measure of biological aging. However, this was a pilot …
Mike Lustgarten presents his detailed food tracking data (54 foods over 41 days) correlated with blood biomarkers showing a 15-year younger biological age via an epigenetic clock. He describes specific dietary experiments targeting DHEA-sulfate improvement …
Longevity self-experimenter Mike Lustgarten documents his supplementation protocol targeting NAD+ levels and homocysteine reduction, measuring outcomes via biological age calculators and blood biomarkers. While he achieved a 48 µM NAD+ level (considered 'optimal' by his …