Epigenetic Clocks — OutliveHub

Preliminary Biomarkers — Aging clocks and measurement tools Observational PubMed

Can a Heart Ultrasound Tell Your True Age?

A simple heart ultrasound with AI software might reveal how much your cardiovascular system has aged, helping catch metabolic problems early.

Researchers used AI to estimate cardiovascular 'biological age' from simple heart ultrasounds in 243 adults. People whose heart appeared older than their calendar age had worse metabolic health markers and were twice as likely to …

European heart journal. Digital health

44 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

A data-driven dietary pattern anchored to slower epigenetic aging is associated with a spectrum of aging-related health outcomes

Diet is an essential factor influencing biological aging, yet few exsiting dietary indices were specifically developed to target biological aging. We developed a data-driven food-based Empirical Dietary Index for Slower Epigenetic Aging (EDISEA) in the …

medrxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other bioRxiv

TranslAGE: A Comprehensive Platform for Systematic Validation of Epigenetic Aging Biomarkers

Epigenetic clocks are powerful biomarkers of biological aging, however, their performance varies across studies and contexts. Current limitations include siloed datasets, inconsistent validation methods, and the absence of a standardized framework for systematic comparison. Here, …

biorxiv (preprint)

34 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

Integrative Proteomic and Metabolomic Signatures of Accelerated PhenoAge in the UK Biobank

Aging is accompanied by molecular changes across multiple biological systems that contribute to functional decline and increased disease risk, but the underlying mechanisms and inter-individual variation remain poorly understood. We investigated whether multi-omics integration can …

medrxiv (preprint)

34 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

Exploring the exposome and unexplained variance in biological ageing - insights from a longitudinal twin study in adolescence and early adulthood

Biological ageing begins before birth, with early-life exposures shaping late-life health. These exposures drive health inequities early, yet specific exposures and the composition of the ageing exposome remain largely undefined. This gap may persist as …

medrxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other medRxiv

Air pollution exposure in Generation Scotland: molecular fingerprints and health outcomes

Ambient air pollution has been associated with increased incidence of chronic disease and is estimated to contribute towards 4.2 million early deaths annually. Whilst the health impacts are well described, less is understood about the …

medrxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Comparing fourteen consensus biomarkers of aging: epigenetic pace of aging as the strongest predictor of mortality in BASE-II.

BACKGROUND: In many countries, lifespan has been increasing faster than healthspan, leading to more years spent with late-life disease and highlighting the need for reliable biomarkers to measure biological aging. METHODS: We used data from …

Biomarker research

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

Does frequency or diversity of leisure activity matter more for epigenetic ageing? Analyses of arts engagement and physical activity in the UK Household Longitudinal Study

Over the past decade, ageing clocks have become widely adopted as important tools for understanding biological ageing and have been redefining notions of "pro-longevity" lifestyles. However, this work is still at an early stage. Some …

medrxiv (preprint)

39 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort.

Epigenetic clocks derived from DNA methylation patterns are among the most promising biomarkers of biological aging1-7, as they capture molecular signatures that predict morbidity and mortality beyond chronological age. Although cross-sectional assessments of epigenetic age …

Nature aging

47 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other medRxiv

Epigenetic Clocks of Biological Aging and Cognitively Healthy Longevity: The Women's Health Initiative Memory Study

BACKGROUND Little is known about whether epigenetic age acceleration (EAA) clocks are capable of predicting exceptional longevity with or without preserved cognitive function. METHODS We examined 5844 women from the Women's Health Initiative Memory Study. …

medrxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation.

Histone modifications represent an untapped resource for biological age prediction that overcomes limitations of traditional DNA methylation-based epigenetic clocks. Here, we developed and validated histone modification-based epigenetic clocks by systematically analyzing publicly available ChIP-seq datasets …

Proceedings of the National Academy of Sciences of the United States of America

46 Early

Preliminary Biomarkers — Aging clocks and measurement tools Observational bioRxiv

Can saliva measure biological aging as well as blood?

Researchers compared DNA methylation aging clocks across three tissue types (saliva, blood cells, and immune cells) in 91 young adults and found that saliva shows different aging patterns than blood, though blood-based samples are interchangeable …

biorxiv (preprint)

31 Early

Preliminary Biomarkers — Aging clocks and measurement tools Cohort Study medRxiv

DunedinPACE epigenetic clock best predicts cognitive decline in older adults

Researchers tested 14 different epigenetic clocks (DNA methylation–based age measures) in over 1,000 older adults and found that DunedinPACE, a newer clock, consistently predicted cognitive decline better than older clocks. This suggests DunedinPACE may be …

medrxiv (preprint)

36 Early

Preliminary Biomarkers — Aging clocks and measurement tools Cohort Study medRxiv

HIV Speeds Up Aging at the Protein Level, But Treatment Reverses It

Researchers created a 'protein aging clock' and found that untreated HIV makes people's proteins look ~6 years older than their actual age. When HIV is treated with antiretroviral therapy, this accelerated aging reverses over time, …

medrxiv (preprint)

36 Early

Promising Biomarkers — Aging clocks and measurement tools Cohort Study PubMed

Which biological aging markers best predict health decline? A 7-year study of 1,083 older adults

Researchers tested 16 different biomarkers of aging (epigenetic clocks, blood proteins, telomeres, and others) in over 1,000 people tracked for 7 years. Two markers—Allostatic Load Index and DunedinPACE—stood out as the most reliable predictors of …

Communications medicine

53 Promising

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

HIV Drug Shows Promise for Slowing Biological Aging in Healthy Adults

Researchers tested whether an FDA-approved HIV medication (tenofovir alafenamide) could slow aging in healthy people by suppressing harmful retrotransposons. Over 12 weeks, the drug showed measurable reductions in epigenetic aging markers, but this is preliminary …

medrxiv (preprint)

29 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Observational medRxiv

The Sleep Sweet Spot: How 6–8 hours connects to biological aging across your whole body

Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …

medrxiv (preprint)

39 Early

Preliminary Biomarkers — Aging clocks and measurement tools Animal Model bioRxiv

How DNA methylation reveals aging in a fish with no genetic variation

Researchers studied a self-fertilizing fish (nearly genetically identical individuals) and found that specific DNA methylation patterns reliably track age with over 96% accuracy. This clean system lets them isolate epigenetic aging from genetic effects, potentially …

biorxiv (preprint)

30 Early

Promising Biomarkers — Aging clocks and measurement tools Cohort Study PubMed

Gene activity patterns reveal how some people stay healthy longer

Researchers analyzed blood gene activity in nearly 2,500 people from long-lived families and found specific genetic signatures associated with aging and survival—including immune system strength and inflammation control. A machine learning model trained on these …

GeroScience

56 Promising

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Randomised Controlled Trial Reddit

Can Polyphenol-Rich Foods Slow Epigenetic Aging?

A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc.

A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc.) was associated with reduced epigenetic age—a molecular measure of biological aging. However, this was a pilot …

Aging Feb 15, 2026

47 Early