Organisms need to be able to adapt to a changing environment in order to survive. The adaptive response invoked by a low dose of a stressor resulting in resistance to high levels of that stressor …
Modulation of mitochondrial dynamics is a viable strategy for lifespan extension. Reactive oxygen species (ROS) play key roles in aging, acting either as signaling molecules to facilitate longevity-associated processes or as stimulators of oxidative stress, …
Manganese (Mn) is an essential trace element, but excessive Mn exposure is associated with neurotoxicity and aging-related dysfunction. Whether Mn overload promotes cellular senescence and the mechanisms involved remain insufficiently defined. Here, we investigated Mn-induced …
Classic psychedelics such as lysergic acid diethylamide (LSD), psilocybin, N,N-dimethyltryptamine (DMT), and mescaline induce lasting changes in neuroplasticity and behavior that extend far beyond their acute pharmacological effects. Emerging evidence highlights that these enduring therapeutic …
Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …
Researchers found that lifelong restriction of valine, a branched-chain amino acid in protein, improved metabolic health and reduced aging markers in both male and female mice, but only extended lifespan in males by 23%. The …
BACKGROUND: Mild intermittent hypoxia is emerging as a promising strategy to enhance healthspan, but the molecular mechanisms remain poorly defined. ADORA2B, a hypoxia-inducible adenosine receptor, is known to regulate metabolism and stress responses, yet its …
BACKGROUND: Cryopreservation causes structural and metabolic damage to stallion spermatozoa, impairing post-thaw functional competence. AIMS/OBJECTIVES: This study evaluated whether cholesterol-loaded cyclodextrin (CLC) supplementation before freezing, combined with pentoxifylline (PTX) after thawing, improves the functional quality, …
Type 1 diabetes (T1D) is an autoimmune disorder characterized by insulin deficiency and hyperglycemia, driven by environmental insults and epigenetic reprogramming beyond genetic predisposition. Recent evidence suggests that systemic epigenetic dysregulation in T1D influences the …
Acute-on-chronic liver failure (ACLF) is a severe liver syndrome marked by systemic inflammation and high mortality, often complicated by autophagy impairment and mitochondrial dysfunction. This study investigates atractylenolide I (AT-1), a compound from Atractylodes macrocephala, …
Cellular senescence is a major driver of age-related tissue dysfunction, characterized by chronic inflammation, oxidative stress, mitochondrial impairment, and disrupted extracellular matrix homeostasis. While senolytic strategies that eliminate senescent cells have shown therapeutic promise, irreversible …
Lysosomal dysfunction is a prominent feature of neurodegeneration and aging, yet how primary defects in lysosomal trafficking are converted into progressive cellular decline remains poorly understood. Niemann Pick disease type C (NPC), caused by impaired …
Brain aging is associated mainly with a decline in cognitive function and is a major risk factor for various neurodegenerative disorders (NDDs). Major hallmarks of aging include oxidative stress, chronic neuroinflammation, mitochondrial dysfunction, and impaired …
Aging is characterized by progressive oxidative stress, mitochondrial dysfunction, chronic inflammation and intestinal barrier impairment, contributing to increased susceptibility to age-associated disorders. Targeting redox imbalance and epithelial dysfunction represents a promising therapeutic strategy to promote …
This review examines ginsenosides—compounds from ginseng—and their potential anti-aging effects through mechanisms like reducing cellular stress and supporting mitochondrial health. While promising in laboratory studies, the authors emphasize that moving from bench science to functional …
Intense pulsed light (IPL)—a common cosmetic treatment—reverses UV sun damage in skin cells by blocking a specific cellular damage pathway (ERK-AP-1-MMP). The study shows this works both in lab-grown human skin cells and in guinea …
Researchers found that a protein called IL33 prevents placental aging; when it's missing, the placenta deteriorates through a chain reaction involving lactate buildup and broken autophagy (cellular cleanup). Senescence-targeting drugs like metformin and dasatinib+quercetin restored …
Cellular senescence is an irreversible program of cell-cycle arrest that accumulates with age, contributing to chronic inflammation and various age-related diseases. A key feature of senescence paradigms is mitochondrial dysfunction, which involves not just a …
Researchers found abnormal mitochondrial function in patients with geographic atrophy (a blinding eye disease) by analyzing fluid from inside the eye. In a small early-stage trial, oral alpha-ketoglutarate supplementation successfully increased the compound's levels in …
PURPOSE: Cellular senescence has emerged as an important mechanism linking renal ageing, acute kidney injury, diabetic kidney disease, chronic kidney disease, renal fibrosis, and kidney transplantation-related injury. This study aimed to map the global research …