The mechanistic target of rapamycin signaling pathway
Researchers mapped the proteins in immortal jellyfish (Turritopsis) that detect environmental stress and decide whether to stay dormant or regenerate. They identified a three-layer signaling architecture centered on mTORC1—a key aging pathway—that could offer clues …
BackgroundGeroprotective interventions, including the mTOR inhibitor rapamycin, slow aging in preclinical models. Translation to humans remains challenging because clinical trials require endpoints detectable within feasible timeframes. Multi-modal in vivo imaging could address this limitation by …
Ovarian aging is characterized by progressive follicular reserve depletion, mitochondrial dysfunction, oxidative stress, and endocrine decline. This review examines the molecular mechanisms driving ovarian aging and evaluates emerging therapeutic strategies to preserve reproductive longevity. Key …
Melanocyte proliferation gene 1 (MYG1) has been implicated in cellular metabolic regulation; however, its role in cardiomyocyte metabolic reprogramming during acute myocardial infarction (AMI) remains unclear. In this study, a rat AMI model was established, …
UNLABELLED: Heat stress significantly disrupts physiological and molecular balance in poultry, leading to oxidative damage, inflammatory responses, and metabolic dysregulation. Among emerging solutions, phytogenic adaptogens have shown promise as natural agents that enhance resilience against …
Researchers gave aging mice rapamycin and found it prevented the normal decline in movement and motor control, with females benefiting more than males. The benefits appear linked to reduced oxidative stress and cellular stress in …
Researchers found that a protein called Dicer-1 in fat tissue acts as a master regulator of aging in fruit flies by controlling insulin levels throughout the body. When Dicer-1 is reduced, it triggers a chain …
Researchers used C. elegans to show that the mTOR protein, when active specifically inside neurons, promotes certain aging changes in nerve cells—particularly the growth of unwanted branches—without affecting overall lifespan. This finding narrows down where …
This review proposes that insulin-like growth factor 1 (IGF-1) acts like a 'switch' for cellular aging—brief exposure helps cells, but chronic exposure drives inflammation and senescence. The authors argue IGF-1 regulation should be a key …
Researchers created an unprecedented atlas of gene activity in 1,675 human muscle biopsies, identifying over 3,000 genes that change with age and discovering that genes linked to muscle wasting in elderly people look strikingly similar …
Researchers identified a protein (CG42795) that, when silenced in neurons, enhances cellular cleanup (autophagy) and extends lifespan in fruit flies. The same mechanism works in human cells, suggesting a new therapeutic target for age-related diseases.
Maternal inflammatory response (MIR) during early gestation in mice induces a cascade of physiological and behavioral changes that have been associated with autism spectrum disorder (ASD). In a prior study and the current one, we …
Geroscience has the goal of extending lifespan through geroprotective interventions. These interventions are typically imparted on groups of individuals, with their efficacy judged by increases in the average age-at-death. A more equitable outcome, which looks …
Immunosenescence, an age-associated decline in immune function, is increasingly recognized as a central determinant of health and disease in older adults. Characterized by thymic involution, loss of naïve T cells, contraction of T cell receptor …
A leading theory for how psychedelics are able to produce robust clinical improvement and preclinical behavioral changes is that psychedelics act through neuroplastic mechanisms to induce lasting structural and functional alterations in neural circuits. However, …
Lysosomes containing multilamellar membrane whorls are a hallmark of cellular aging and storage disorders, yet the biogenesis of these structures has remained elusive for decades. Here, we identify a distinct form of endoplasmic reticulum (ER) …
BACKGROUND: Immunothrombosis entails a tight interplay between thrombotic and inflammatory pathways and plays a pathological role in ischemic stroke and venous thrombosis. The mTOR (mechanistic target of rapamycin) is a canonical serine/threonine kinase and is …
In this study, the effect of dietary taurine (Tau) on the innate immune responses, digestive function, and mammalian target of rapamycin (RAPA; mTOR) signaling was investigated in coho salmon (Oncorhynchus kisutch). Coho salmon were fed …
Focal cortical dysplasia type II (FCDII), a major cause of pediatric drug-resistant focal epilepsy, results from brain somatic variants in mTOR pathway genes, including germline and somatic second-hit loss-of-function variants in the mTOR repressor DEPDC5. …
Heterozygous mutations in the Glucocerebrosidase gene (GBA1), encoding the lysosomal hydrolase Beta-glucocerebrosidase (GCase), are a genetic risk factor for Parkinsons disease (PD). To explore the pathophysiological consequences of these mutations, we have used fibroblasts and …