Proteomics, metabolomics, transcriptomics, and multi-omics aging studies
OBJECTIVE: Global growth hormone receptor knockout (GHR-/-) extends lifespan but also causes adverse effects. As a key target of growth hormone (GH), adipose tissue may mediate aging, though the underlying mechanisms remain unclear. We investigated …
Ageing is marked by widespread cortical changes, but the molecular underpinning and network connectivity shaping this variability remain poorly understood. We analysed structural MRI from 952 adults aged 18-94 using morphometric similarity networks, subtype/stage inference, …
Gut microbiota resilience, the capacity of intestinal microbial communities to resist, adapt, and recover from perturbations has emerged as a critical determinant of human health and longevity. Environmental stressors such as antibiotics, pollutants, poor diet, …
Pulmonary tuberculosis (TB) exhibits marked spatial heterogeneity, with alveolar pneumonia and organized granulomas frequently coexisting within the same lung. While granulomas have long dominated conceptual models of TB pathogenesis, the immune programs operating within alveolar …
Aging is accompanied by molecular changes across multiple biological systems that contribute to functional decline and increased disease risk, but the underlying mechanisms and inter-individual variation remain poorly understood. We investigated whether multi-omics integration can …
Focal cortical dysplasia type II (FCDII), a major cause of pediatric drug-resistant focal epilepsy, results from brain somatic variants in mTOR pathway genes, including germline and somatic second-hit loss-of-function variants in the mTOR repressor DEPDC5. …
Mammalian ovary development is essential for female fertility, involving the complex spatial patterning of diverse cell types to establish the finite reserve of ovarian follicles. To uncover molecular mechanisms driving regionalization of the ovary while …
This study aimed to investigate the metabolic mechanisms and identify potential biomarkers of resilience and longevity by comparing divergent functional longevity lines and phenotypic resilience groups in dairy goats. A total of 70 Alpine goats, …
Researchers developed Personal-MetaboHealth, a blood-based score that predicts heart disease and mortality risk in middle-aged people, and showed it improves with a 3-month lifestyle intervention. The test could become a practical screening tool for early …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
The increasing demand for natural food preservatives has intensified research into indigenous microorganisms with biopreservative properties. This study investigated the antimicrobial efficacy and biopreservative potential of lactic acid bacteria (LAB) isolated from traditionally fermented Dacryodes …
Population ageing has widened the gap between lifespan and healthspan, with frailty and functional dependence increasingly shaping late-life outcomes. Yet trajectories in older age remain highly heterogeneous, suggesting that vulnerability is not determined by chronological …
The decline in ovarian function with age affects fertility and is associated with increased risk of age-related diseases, including osteoporosis and dementia. Notably, earlier menopause is linked to shorter lifespan, yet the molecular mechanisms underlying …
BACKGROUND: Centromere identity in eukaryotes is defined epigenetically by CENH3 (CENPA), a specialized histone H3 variant essential for kinetochore establishment and faithful chromosome segregation. However, the regulatory mechanisms governing CENH3 loading during meiosis and how …
Researchers compared gut bacteria in people aged 45–59, 60–89, and 90+ and found that centenarians have distinctly different microbial communities—richer in beneficial bacteria like Akkermansia and enriched in pathways that produce fatty acids and other …
This collection brings together 16 studies from researchers worldwide showing that circadian rhythms—your body's 24-hour internal clock—play a central role in aging and longevity. By understanding how these rhythms break down with age, scientists are …
Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …
The human striatum is a central hub for diverse motor, cognitive, and affective behaviors, yet it lacks obvious cytoarchitectural boundaries defining functional territories. Here, we uncover a robust and molecularly defined mesoscale architecture in the …
Researchers used a new technique to map proteins on the surface of brain glial cells in fruit flies and found that a protein called DIP-β declines with age. When they artificially increased DIP-β in the …
Psoriasis is a chronic, immune-mediated dermatological disorder characterized by hyperproliferation of keratinocytes and dysregulated immune signaling. Although genome-wide association studies (GWAS) have identified susceptibility loci, the disease's multifactorial nature underscores the importance of non-genetic regulatory …