As people age, their immune systems weaken, which may reduce how well cancer immunotherapy works—especially in patients over 75. Researchers are testing mRNA-based approaches and senolytics (drugs that clear damaged cells) to reverse this immune …
This review proposes that insulin-like growth factor 1 (IGF-1) acts like a 'switch' for cellular aging—brief exposure helps cells, but chronic exposure drives inflammation and senescence. The authors argue IGF-1 regulation should be a key …
Researchers tested whether dasatinib and quercetin—drugs that eliminate senescent (aging) cells—could prevent bone loss in the jaw. The treatment worked in naturally aged mice but failed in a gum disease model, suggesting senolytic benefits may …
This is a protocol paper describing an upcoming clinical trial that will test whether three drugs (metformin, fisetin, and spermidine) can reduce senescent cells and reverse aging hallmarks in healthy adults over 70 within three …
Researchers developed a new tool to watch autophagy (cellular recycling) in real time in naked mole-rat cells and discovered that these long-lived animals respond to stress by forming temporary vacuoles—a protective response that reverses when …
Researchers treated female mice with fatty liver disease (MASLD) using senolytic drugs—compounds that eliminate senescent (aged) cells—and found pregnancy rates improved, particularly through reduced aging and inflammation in the ovaries. However, the treatment had limited …
Researchers found that demethyleneberberine (DMB), a natural compound from tree bark, can reverse signs of cellular aging in human fibroblasts and extend lifespan in C. elegans by activating a DNA repair enzyme called FEN1. While …
Aging is a primary risk factor for disease progression in multiple sclerosis (MS). Because of this, treatments that can reduce the consequences of molecular aging, like senescence, have been proposed as a strategy to address …
Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy …
BACKGROUND: People with HIV (PWH) experience chronic inflammation and more age-related comorbidities despite antiretroviral therapy (ART). Classical senescence biomarkers (e.g., SA-βGal, p16INK4a, γH2AX and Bcl-2) and senescence-associated secretory phenotype (SASP) factors such as IL-6 reflect …
Cellular senescence is an irreversible program of cell-cycle arrest that accumulates with age, contributing to chronic inflammation and various age-related diseases. A key feature of senescence paradigms is mitochondrial dysfunction, which involves not just a …
The rising incidence of neurodegenerative disorders linked to protein fibrillation in aging populations highlights the need for efficient, low-toxicity fibrillation inhibitors. Quercetin, a natural flavonoid, shows potential in both suppressing fibrillation and disaggregating mature fibrils. …
Immunosenescence, an age-associated decline in immune function, is increasingly recognized as a central determinant of health and disease in older adults. Characterized by thymic involution, loss of naïve T cells, contraction of T cell receptor …
Alzheimer's disease (AD), a prevalent neurodegenerative disorder characterized by cognitive impairment and neuronal degeneration, is increasingly recognized as being driven not only by the traditional amyloid-beta and tau pathologies but also by persistent neuroinflammation and …
A Reddit post discusses a study showing that exercise removes senescent (damaged) cells from muscle tissue, reactivates stem cells, and improves insulin sensitivity in middle-aged adults with obesity. The post frames exercise as a cellular-level …
This review explains how the immune system becomes dysfunctional with age, leading to chronic inflammation and organ damage that accelerates aging across the entire body. The authors argue that restoring immune function could be a …
This review explains how aging accelerates Alzheimer's disease by disrupting multiple biological systems—from amyloid clearance to immune function to circadian rhythms. The authors propose that targeting aging mechanisms themselves, rather than individual AD symptoms, could …
Researchers discovered that HMGB1, a protein released by aging cells, can trigger aging in healthy cells when it's in a specific damaged form—but not when it's oxidized. Blocking this protein in mice reduced aging markers …
This review examines how CXC chemokines—signaling proteins released by aging cells—contribute to age-related diseases and cancer. The authors propose these molecules could become biomarkers for aging and targets for new longevity therapies, though most evidence …
This review synthesizes evidence that polyamines—small molecules that naturally decline with age—regulate multiple aging pathways including oxidative stress, gene expression, and protein synthesis. While animal studies show spermidine supplementation extends lifespan, human evidence remains limited, …