Stem cell exhaustion, regeneration, and rejuvenation
Bone marrow (BM) mesenchymal stem cells (BM-MSCs) have a crucial role in BM homeostasis and regenerative therapy. While lipids are known to be fundamental components of metabolism, their precise role in modulating the function and …
Exosomes are nanoscale extracellular vesicles that facilitate intercellular communication by transporting regulatory molecules, such as microRNAs, proteins, and lipids. Acting as "software updates" for cells, exosomes influence gene expression and cellular behavior without altering the …
Researchers discovered that aging planarians (regenerative flatworms) lose fertility not because their stem cells fail, but because their body's positional 'blueprint' gradually shifts out of alignment. By manipulating the molecular signals that control body polarity, …
BACKGROUND: Photoaging represents a significant clinical challenge with limited effective therapeutic interventions capable of reversing established UV-induced damage. While conventional laser therapies rely on thermal mechanisms with associated complications, picosecond laser-induced optical breakdown (LIOB) offers …
This review examines 'partial reprogramming'—a technique that temporarily activates rejuvenation factors to reverse aging hallmarks in cells and tissues without turning them into cancer-prone stem cells. Early evidence suggests it can restore tissue function and …
Ageing of human skin is driven in part by cumulative damage to extracellular matrix (ECM) proteins, resulting in wrinkles, laxity, and reduced capacity to heal. Bioactive peptide matrikines are promising therapeutic agents capable of stimulating …
Biallelic pathogenic variants in STRADA (STE20-related adaptor alpha), an upstream regulator of the mechanistic target of rapamycin (mTOR) pathway, result in megalencephaly, drug-resistant epilepsy, and severe intellectual disability. This study explores how mTOR pathway hyperactivity …
Frailty, a syndrome that decreases healthspan in older individuals, lacks effective therapies. We conducted a randomized, dose-finding clinical trial to test whether human bone marrow-derived allogeneic mesenchymal stem cells (MSCs; laromestrocel) improve physical functioning and …
Radiotherapy-induced skin fibrosis is a chronic progressive complication of radiotherapy that impairs function, aesthetics, and quality of life yet remains under-recognized and undertreated. While acute cutaneous toxicities are typically transient, chronic sequelae such as fibrosis, …
Glioblastoma is a highly aggressive primary brain tumour marked by extensive genomic and epigenomic alterations, cellular heterogeneity, and therapeutic resistance. Despite maximal surgical resection followed by chemoradiotherapy, median survival remains approximately 15 months, reflecting the …
INTRODUCTION: Skin aging arises from intrinsic processes and extrinsic insults (e.g., ultraviolet exposure and oxidative stress). Mesenchymal stromal cell (MSC)-derived secretome offers a cell-free approach to skin regeneration. Wharton's jelly-derived MSCs (WJ-MSCs) may outperform adipose-derived …
Aging is a primary risk factor for disease progression in multiple sclerosis (MS). Because of this, treatments that can reduce the consequences of molecular aging, like senescence, have been proposed as a strategy to address …
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a dismal 5‑year survival rate of ~9%, primarily due to late diagnosis, aggressive metastasis and profound resistance to conventional therapies. Epithelial‑mesenchymal transition (EMT) …
Drugs like semaglutide (a.k.a. Ozempic/Wegovy) that activate the glucagon-like peptide-1 receptor (GLP-1R) are a promising therapy for obesity and type 2 diabetes (T2D). Animal studies suggest that these drugs likely function by stimulating GLP-1R on …
Researchers mapped the proteins in immortal jellyfish (Turritopsis) that detect environmental stress and decide whether to stay dormant or regenerate. They identified a three-layer signaling architecture centered on mTORC1—a key aging pathway—that could offer clues …
Researchers developed a method to rejuvenate aging mesenchymal stem cells (MSCs) by temporarily expressing three genes via a non-integrating virus, then removing the virus. The rejuvenated cells showed extended lifespan, restored telomeres, and maintained their …
BACKGROUND: Stem cells residing in the perivascular niche are critical for skeletal homeostasis. Vascular endothelin-1 (ET-1) controls stem cell fate in development, but its role in the exhaustion of skeletal stem cells (SSCs) and subsequent …
The digestive tract represents the most complex interface of an organism with its biotope. Food may be contaminated by pathogens and toxicants while an abundant and complex microbiota thrives in the gut lumen. The organism …
Researchers found that caloric restriction slows aging of hematopoietic stem cells (blood-forming cells) in mice by activating specific genes like KDR and PU.1 that control whether these cells self-renew or differentiate. The discovery identifies molecular …
Mesenchymal stem cell (MSC)-derived exosomes are emerging as cell-free bioregenerative platforms in aesthetic dermatology. Umbilical cord (UC-MSC) and adipose-derived (AD-MSC) exosomes are among the most studied sources, yet existing data derive from heterogeneous models that …