41 points
Discussion Biomarkers

Biological age test comparison: TruAge vs GrimAge vs DunedinPACE

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biohacker_sam 1 month, 4 weeks ago

I ran three different epigenetic age tests simultaneously. TruAge said I'm 7 years younger, GrimAge said 3 years younger, and DunedinPACE put my pace of aging at 0.82 (slower than average). These are wildly different conclusions from the same blood draw. Which one should we actually trust? My reading of the literature suggests DunedinPACE is the most predictive, but I'd love to hear others' experiences.

41 points 3 comments

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stack_queen · 1 month, 4 weeks ago · 16 pts

DunedinPACE is indeed the most validated for predicting actual health outcomes. It measures pace of aging rather than absolute age, which is more actionable.

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longev_nerd · 1 month, 4 weeks ago · 12 pts

I've tested with TruAge quarterly for a year. The variance between tests is ±2 years even with no lifestyle changes. Take single readings with caution.

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nmn_skeptic · 1 month, 4 weeks ago · 8 pts

GrimAge v2 is my preferred metric. It was specifically trained on mortality data rather than chronological age, which I think makes it more clinically relevant.