34 points
Protocol Pharmacological

Fisetin as a senolytic — protocol and experience

D
dr_mito 1 month, 3 weeks ago

Following the Mayo Clinic dosing protocol: 20mg/kg for 2 consecutive days, repeated monthly. I've done 4 cycles now. Subjectively, I notice reduced joint stiffness for about 2 weeks after each cycle, and my inflammatory markers (hsCRP, IL-6) have trended down. No significant side effects besides mild GI discomfort on dosing days. Curious what others are experiencing.

34 points 3 comments

Comments

Best New
E
epigenetic_age · 1 month, 3 weeks ago · 10 pts

The bioavailability of fisetin is terrible without lipid co-administration. Are you taking it with a fatty meal?

S
stack_queen · 1 month, 3 weeks ago · 7 pts

I tried this same protocol but with quercetin + dasatinib instead. Similar joint improvements but the side effects were more noticeable.

E
epigenetic_age · 1 month, 3 weeks ago · 6 pts

Has anyone seen actual senescent cell burden measured before/after? The subjective reports are nice but we need real data.