40 points
Discussion Pharmacological

The case for vitamin D supplementation in longevity

S
sleep_hacker 1 month, 4 weeks ago

Large meta-analyses keep showing that vitamin D supplementation reduces all-cause mortality by ~6%. The VITAL trial showed reduced cancer mortality. Yet most longevity experts barely mention it because it's boring and cheap. I maintain 60-80 ng/mL with 5000 IU daily + K2. At $10/year, this might be the highest ROI longevity intervention available.

40 points 4 comments

Comments

Best New
S
senolytics_fan · 1 month, 4 weeks ago · 22 pts

$10/year for a 6% mortality reduction. If this were a new drug it would be the biggest blockbuster in pharma history.

S
stack_queen · 1 month, 4 weeks ago · 15 pts

The K2 pairing is crucial and often overlooked. Without K2, vitamin D can lead to calcium ending up in arteries rather than bones.

Z
zone2_mike · 1 month, 4 weeks ago · 9 pts

The 60-80 ng/mL target is higher than mainstream medicine recommends (30-50). What's your evidence for the higher range?

D
dr_mito · 1 month, 4 weeks ago · 7 pts

Make sure you're taking D3, not D2. And test your levels — there's significant individual variation in response to supplementation.