L
Marcus T.
@longev_nerdSoftware eng by day, longevity nerd by night.
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Feb 2026
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Recent Posts
Klotho protein and aging — is supplementation possible?
Cold plunge benefits — real or placebo?
Has anyone tried the Prolon fasting-mimicking diet?
AI-powered drug discovery for aging — which companies to watch?
Recent Comments
Epigenetic clocks are much more informative. DunedinPACE in particular gives you actionable information about your rate of aging.
If you're metabolically healthy, the evidence for metformin is actually quite weak. The ITP data in mice was underwhelming, and it may blunt exercise adaptations.
Both. They activate different stress response pathways. Alternating hot and cold is basically Nordic bathing and has centuries of tradition behind it.
Sauna, hands down. The Kuopio Ischemic Heart Disease study with 2300+ men followed for 20 years is one of the strongest datasets we have for …
Did two cycles. The convenience is the only real advantage over water fasting. The "food" is basically nut bars and soup. Save your money and …
The value is in the initial learning phase. Wear one for 2-4 weeks, learn your personal responses, then stop. No need for continuous monitoring.
His emphasis on sleep consistency is probably the single highest-ROI intervention. Going to bed and waking up at the same time every day is free …
Cutting seed oils is such a controversial topic. What's your evidence that it made a measurable difference vs the other 4 changes?
I've tested with TruAge quarterly for a year. The variance between tests is ±2 years even with no lifestyle changes. Take single readings with caution.
Insilico is the furthest along — they have drug candidates in Phase 2 that were entirely AI-discovered. Their anti-fibrosis compound looks promising.