S
Jordan L.
@senolytics_fanFollowing senolytic research since 2019.
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Feb 2026
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The targeted approach is smart — instead of broad senolytics that kill everything, they specifically target p16+ cells. Much cleaner.
The Valter Longo research behind it is legit, but you can replicate the macros yourself for a fraction of the cost. Lots of DIY FMD …
Disagree — I found huge value in seeing how stress and sleep affect my glucose independently of food. That insight alone was worth it.
Unpopular opinion: the Blueprint diet is just Mediterranean diet with extra steps and a PR team.
I think the real value is the measurement obsession. Getting regular bloodwork and tracking trends is something everyone should do, regardless of budget.
I wonder if the dog metabolism makes direct dose translation tricky. The allometric scaling might not be straightforward.
$10/year for a 6% mortality reduction. If this were a new drug it would be the biggest blockbuster in pharma history.
2x/week full body with compound movements is plenty for longevity purposes. You're not training for a powerlifting meet. Focus on progressive overload and consistency.
Calico has been disappointing honestly. Google money and 10 years of work with very little to show in terms of clinical pipeline.
I had similar lipid issues in the first 3 months. My doctor added low-dose rosuvastatin and it resolved. Worth discussing with yours.