This systematic review evaluates the effectiveness of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) for periorbital rejuvenation, updating a previous 2021 review. Twenty-six studies were included with notable variability in preparation methods limiting clear conclusions. Patient satisfaction was high with PRP/PRF treatment, which was only moderately effective for periorbital hyperpigmentation, and objective improvements for wrinkles and skin texture were mixed. Clinical use is described.
Platelet-Rich Plasma and Platelet-Rich Fibrin in Periorbital Esthetics: Systematic Review and Clinical Applications.
TL;DR
This systematic review evaluates the effectiveness of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) for periorbital rejuvenation, updating a previous 2021 review. Twenty-six studies were included with notable variability in preparation methods limiting clear conclusions. Patient satisfaction was high with PRP/PRF treatment, which was only moderately effective for periorbital hyperpigmentation, and objective improvements for wrinkles and skin texture were mixed. Clinical use is descri
Credibility Assessment
Promising — 51/100
Study Design
Rigor of the research methodology
18/20
Sample Size
Whether the study was sufficiently powered
7/20
Peer Review
Review status and journal reputation
10/20
Replication
Has this finding been independently reproduced?
6/20
Transparency
Funding disclosure and data availability
10/20
Overall
Sum of all five dimensions
51/100
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