FDA/EMA pathways and regulatory frameworks for aging interventions
Senescent endothelial cells (ECs), characterized by a reduced angiogenic and regenerative potential, are key players in the pathophysiology of cardiovascular diseases. Therefore, targeting these cells has been suggested as an effective therapeutic strategy to increase …
The bone marrow niche (BMN) plays a central role in regulating hematopoietic stem-cell (HSC) maintenance, lineage commitment, and immune homeostasis, while also supporting osteogenesis and maintaining skeletal integrity. Once considered static, the BMN is now …
INTRODUCTION: Skin aging, marked by wrinkles, volume loss, and reduced hydration, has driven growing interest in minimally invasive aesthetic treatments to restore skin quality and appearance. This study aimed to evaluate the efficacy and safety …
In this study, we examined resident preferences for prospective end-of-life management of a coastal wind farm in Japan through a case study of an 11-turbine, 22 MW installation, based on a questionnaire survey of 218 …
AIMS: Numerous preclinical studies suggested that targeted inhibition of mammalian target of rapamycin (mTOR) may be beneficial for the treatment of osteoporosis. However, the relevance of these findings to human populations remains unclear. We hypothesized …
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, highlighting the urgent requirement for innovative therapeutic strategies. Cytisine N-methylene-(4',5,7-trihydroxy)-isoflavone (named CNI3), a natural derivative of cytisine N-isoflavone isolated from Sophora alopecuroides …
BACKGROUND: Poly-L-lactic acid (PLLA) is a biostimulatory injectable that restores midfacial volume through collagen neogenesis rather than gel-based filling. Controlled clinical evidence directly quantifying PLLA's volumetric efficacy remains limited. OBJECTIVES: To evaluate the efficacy, safety, …
Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …
Classic psychedelics such as lysergic acid diethylamide (LSD), psilocybin, N,N-dimethyltryptamine (DMT), and mescaline induce lasting changes in neuroplasticity and behavior that extend far beyond their acute pharmacological effects. Emerging evidence highlights that these enduring therapeutic …
PURPOSE: Spermidine administration ameliorates hepatic steatosis and cardiometabolic dysfunction in animal models. However, evidence in humans remains limited. We aimed to explore the 1-year longitudinal associations between changes in dietary spermidine intake and changes in …
Researchers gave aging mice rapamycin and found it prevented the normal decline in movement and motor control, with females benefiting more than males. The benefits appear linked to reduced oxidative stress and cellular stress in …
Monocytes and macrophages are critically involved in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Accumulating evidence indicates that monocytes and macrophages can develop innate immune memory and exhibit sustained pro-inflammatory properties in response to stimuli …
In many animal species, individuals acquire knowledge from others that enhances their survival and reproduction. However, among the many available cultural exemplars, not all provide reliable information. Consequently, individuals tend to choose their exemplars selectively. …
Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …
This review examines how anti-aging interventions affect males and females differently, exploring whether sex differences stem from baseline lifespan variations, body composition, metabolism, or hormone/chromosome differences. The authors argue that treating sex as a biological …
Bisdemethoxycurcumin (BDMC) is a natural curcuminoid with higher solubility and stability than curcumin, yet its potential role in lifespan and healthspan regulation remains largely unexplored. This study aimed to investigate the effects of BDMC on …
This review examines ginsenosides—compounds from ginseng—and their potential anti-aging effects through mechanisms like reducing cellular stress and supporting mitochondrial health. While promising in laboratory studies, the authors emphasize that moving from bench science to functional …
T cell exhaustion (TCE), a hallmark of chronic infections and cancer, is characterized by progressive loss of effector function, sustained expression of inhibitory receptors, and stable transcriptional/epigenetic reprogramming. Within the tumor microenvironment (TME), exhausted CD8+ …
Background The 2026 multisociety guideline frames cardiovascular, kidney, and metabolic health as a staged pathway. National surveillance should distinguish early-risk expansion from advanced-disease accumulation because they require different responses. Methods We analysed 66,553 adults aged …
The neighborhoods children grow up in are associated with cognitive and mental health outcomes across the lifespan. Yet how neighborhood-level factors are quantified, and how they relate to large-scale functional brain connectivity, remains an emerging …