Molecular markers that predict biological age and healthspan
Histone modifications represent an untapped resource for biological age prediction that overcomes limitations of traditional DNA methylation-based epigenetic clocks. Here, we developed and validated histone modification-based epigenetic clocks by systematically analyzing publicly available ChIP-seq datasets …
Over the past decade, ageing clocks have become widely adopted as important tools for understanding biological ageing and have been redefining notions of "pro-longevity" lifestyles. However, this work is still at an early stage. Some …
Background and Objectives: Biological age, reflecting the cumulative molecular and cellular damage such as telomere attrition, epigenetic alterations and mitochondrial dysfunction, may better capture age-related decline and Alzheimer's disease (AD) risk than chronological age. Most …
Researchers found that coordinated control of proteasome subunit genes—the cellular recycling machinery—is critical for longevity in C. elegans. When this coordination breaks down, even genetic interventions that normally extend lifespan fail, suggesting proteostasis balance is …
Researchers found abnormal mitochondrial function in patients with geographic atrophy (a blinding eye disease) by analyzing fluid from inside the eye. In a small early-stage trial, oral alpha-ketoglutarate supplementation successfully increased the compound's levels in …
Researchers developed a new tool to watch autophagy (cellular recycling) in real time in naked mole-rat cells and discovered that these long-lived animals respond to stress by forming temporary vacuoles—a protective response that reverses when …
A protein called klotho, known to extend lifespan and boost brain function, appears to protect people with Parkinson's disease from cognitive decline—at least in genetic studies and mouse models. Researchers found that higher klotho levels …
This review examines whether infusing young plasma can rejuvenate aging bodies, a concept supported by animal experiments but largely unproven in humans. The authors argue that while preclinical models show promise, current clinical applications of …
This review synthesizes evidence that natural killer (NK) cells—a type of immune cell—undergo age-related changes that impair their ability to clear damaged cells and regulate inflammation, contributing to aging-related diseases. The authors propose NK cell …
Researchers developed an AI model that estimates biological age from retinal photographs and found it correlates strongly with cardiovascular, kidney, and metabolic disease markers in over 30,000 people. This suggests eye imaging could become a …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
Researchers developed a standardized method to adapt epigenetic aging clocks—which measure biological age through DNA methylation patterns—from older microarray technology to newer sequencing platforms using cell-free DNA. This is important because sequencing is becoming the …
This review examines how chemical modifications to RNA molecules regulate telomere maintenance—the process that prevents chromosome shortening and cellular aging. The authors propose that understanding these epitranscriptomic controls could reveal new targets for treating aging-related …
Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …
Researchers studied 3,703 adults over 90 and 22,354 younger adults to identify genetic variants linked not just to living longer, but to living longer *well*. They found that certain genes (APOE, APOC1) are associated with …
Biological age estimators quantify aging-related variation but provide limited insight into organ-specific aging processes. The retina enables non-invasive visualization of microvascular and neural structures and has emerged as a promising modality for biological age prediction. …
Biological ageing begins before birth, with early-life exposures shaping late-life health. These exposures drive health inequities early, yet specific exposures and the composition of the ageing exposome remain largely undefined. This gap may persist as …
Researchers mapped the proteins in immortal jellyfish (Turritopsis) that detect environmental stress and decide whether to stay dormant or regenerate. They identified a three-layer signaling architecture centered on mTORC1—a key aging pathway—that could offer clues …
Epigenetic clocks estimate biological age from DNA methylation patterns at CpG sites, providing robust predictions of mortality and morbidity risk. "Blue zones"--regions of exceptional longevity--offer a unique opportunity to investigate how biological aging diverges from …
Researchers analyzed blood chemistry in 213 people over 100 years old and found they have distinctly different metabolic profiles—especially higher bile acids and lower inflammatory markers—compared to younger controls. By identifying these metabolic signatures, they …