Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging
UNLABELLED: Immune evasion driven by the tumor microenvironment is a major obstacle to effective immunotherapy in gastric cancer. To overcome this barrier, a detailed understanding of the mechanisms by which gastric cancer circumvents antitumor immunity …
Different definitions have been proposed for longevity, making it challenging to compare methods for estimating the economic significance of survival traits. Simple profit functions often fail to capture biological complexity, whereas bioeconomic models, though comprehensive, …
Researchers studied over 420 long-lived families across three generations and found that people who inherit fewer genetic risk factors for heart disease—particularly genes affecting cholesterol—tend to live longer and healthier lives. This suggests that staying …
Researchers studied rats bred for high and low running capacity and found that genes controlling muscle enhancers—regulatory DNA regions—drive differences in cardiorespiratory fitness by reshaping how cells handle energy and oxygen. This molecular map could …
Over the past decades, numerous studies aimed to discover the fundamental cause of the aging process. Rather than a single root cause, multiple factors were identified, suggesting that aging manifests itself through a progressive degradation …
Aspartame (ASP) is a common artificial sweetener used in food and beverages. There is currently significant controversy surrounding the safety of aspartame. However, the molecular mechanisms of aspartame on innate immunity and lifespan remain poorly …
How aging of human neurons affects dynamics of essential organelle such as mitochondria and autophagosomes remains largely unknown. MicroRNA-induced directly reprogrammed neurons (miNs) derived from adult fibroblasts retain age-associated signatures of the donor, enabling the …
Mitochondrial short-chain enoyl-CoA hydratase 1 deficiency (ECHS1D) is a rare and severe encephalopathy linked to neurodevelopmental disorders, yet the connection between metabolic dysfunction and impaired neurogenesis remains unclear. In this study, we demonstrate that the …
The biological feasibility of human rejuvenation remains a subject of intense debate, yet answering this question is critical for guiding research strategies. Should aging research focus only on reversing aging in older individuals, or pausing …
After fertilization in mammals, there is an epigenetic asymmetry reflected by differences in DNA demethylation and histone modifications between female and male pronuclei (FPN and MPN, respectively). Based on its expression level and amount, we …
Peripheral arterial disease (PAD) is characterized by impaired angiogenesis, yet the molecular mechanisms linking metabolic dysregulation to epigenetic reprogramming in endothelial cells (ECs) remain poorly understood. Here, we identify hexokinase 2 (HK2) as a critical …
Maintenance of the genome and epigenome stability is vital for animal longevity. Long noncoding RNAs, roX1 and roX2, are known to be important in the male X chromosome dosage complex in Drosophila males. However, their …
Environmental factors are often detrimental; however, certain environments enhance immune resilience. Notably, children raised on traditional farms show reduced allergies and asthma prevalence. Here, we investigated how a beneficial environment, using farm dust (FD) extract, …
Meiotic chromosome pairing requires the establishment of a polarized nuclear architecture, but how this polarity emerges from the interplay of telomeres, the nucleolus, and the nuclear envelope remains incompletely understood in plants. Using stage-resolved three-dimensional …
Hematopoietic stem cells (HSCs) transition through different functional states throughout life from emergence and expansion in the fetus, homeostasis maintenance in adulthood, and progressive functional decline with age. Aged HSCs are characterized by increased phenotypic …
Angiogenesis fuels colorectal cancer (CRC) growth and metastasis by supplying oxygen and nutrients to expanding tumors. Here, we define a TGM2-mediated serotonylation axis in tumor endothelial cells as a driver of angiogenesis and a key …
Telomeres gradually shorten at each cell division, and telomerase counteracts this shortening by elongating telomere sequences. This dynamic balance between elongation and shortening results in a steady-state telomere length (TL) distribution. Here, we develop a …
Researchers sequenced genomes from 8 related bat species and found that bats evolved special adaptations to fight DNA viruses—and these same adaptations appear linked to cancer resistance and extended lifespans. This suggests that the ability …
Alternative lengthening of telomeres (ALT) is a specialized telomere extension mechanism associated with 5-10% of all cancers1. Although ALT has been linked to epigenetic dysregulation and genome instability, specific genomic and epigenetic rearrangements generated after …
Gliomas account for ∼80% of primary malignant brain tumors. Many CNS WHO grade 2-3 and some grade 4 gliomas harbor mutant isocitrate dehydrogenase 1 (mIDH1), which causes a gain-of-function mutation (IDH1 R132H) leading to the …