Researchers found that a protein called Dicer-1 in fat tissue acts as a master regulator of aging in fruit flies by controlling insulin levels throughout the body. When Dicer-1 is reduced, it triggers a chain …
Geroscience has the goal of extending lifespan through geroprotective interventions. These interventions are typically imparted on groups of individuals, with their efficacy judged by increases in the average age-at-death. A more equitable outcome, which looks …
BACKGROUND: In animal models, caloric restriction (CR) and time-restricted eating (TRE) extend lifespan and healthspan; however, the long-term benefits in humans are unknown. The goal of the Health, Aging and Later-Life Outcomes Pilot (HALLO-P) was …
BACKGROUND: The majority of bacteria in the vertebrate gut harbor integrated bacterial viruses ("bacteriophages" or "phages"; integrated phage are termed "prophages"). To probe phage replication strategies in the mammalian gut microbiome, we investigated phage activity …
Different types of dietary restriction (DR) have been practiced by humans for religious and medical purposes for millennia, but only during the past three decades has the scientific study of DR at cellular and molecular …
Several if not all manifestations of aging can be postponed by a healthy lifestyle involving a balanced diet coupled with regular exercise and sufficient sleep. Similarly, various genetic and pharmacological longevity interventions can exert beneficial …
OBJECTIVE: To investigate the long-term metabolic and hormonal consequences of sustained weight loss versus weight regain after 1 year of caloric restriction (CR), with attention to insulin resistance and type 2 diabetes risk. RESEARCH DESIGN …
Researchers found that cutting calorie intake by 50% in mice slowed age-related damage to the liver and kidneys, reducing fibrosis, metabolic stress, and cellular senescence markers. The protective effect appeared linked to activation of SIRT1, …
Researchers tested intermittent fasting in 10 genetically distinct mouse strains and found that how much fasting improves health and lifespan depends heavily on your genes and sex—not just the diet itself. This suggests that personalized …
Researchers found that female fruit flies on very low-cholesterol diets had shorter lifespans and developed leaky gut problems. Interestingly, not all flies showed gut damage before dying, suggesting cholesterol may be essential for maintaining intestinal …
Researchers found that caloric restriction slows aging of hematopoietic stem cells (blood-forming cells) in mice by activating specific genes like KDR and PU.1 that control whether these cells self-renew or differentiate. The discovery identifies molecular …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
Dr. Brad Stanfield critically examines the NAD-boosting supplement trend, tracing it from compelling animal studies to disappointing human clinical trials and failed reproducibility attempts. He argues that despite initial excitement around NMN and NR supplements, …
A study of over 100,000 UK adults found that five well-known healthy eating patterns—from Mediterranean to plant-based diets—were each associated with 1.5–3 extra years of life by age 45, with benefits holding true regardless of …
When male rats ate 15% fewer calories for just 2 weeks, their brown fat (heat-generating tissue) adapted by storing more fat droplets while maintaining its ability to burn energy and produce heat. These coordinated metabolic …
This video presents rodent evidence that surgical visceral fat removal extends lifespan, then applies those findings to the creator's personal DEXA scan data showing he maintains unusually low visceral fat (127g vs. ~1300g expected for …
Beta-hydroxybutyrate (BHB), a ketone body produced during ketogenic diets and caloric restriction, correlates with lifespan extension in mice and appears mechanistically linked to longevity through glucagon signaling. The video presents mouse model data showing BHB's …
Researchers fed fruit flies 20 different types of cereal grains and found that female flies lived 3-13% longer while males lived up to 19% shorter, depending on the cereal type. The sex-specific effects appear linked …
Limiting food intake to an 8-hour window reduced CRP and IL-6 levels by 25% in overweight adults.