Human clinical trials testing longevity interventions
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a dismal 5‑year survival rate of ~9%, primarily due to late diagnosis, aggressive metastasis and profound resistance to conventional therapies. Epithelial‑mesenchymal transition (EMT) …
BackgroundDespite evidence that quitting smoking improves cancer treatment and outcomes, about one in eight patients with cancer smokes cigarettes. Barriers to quitting for patients with cancer include psychological distress such as anxiety and hopelessness and …
Researchers found that losartan, a common blood pressure medication, shifted the metabolic fingerprint of aged mice and pre-frail older men toward a younger state. The effect appeared dose-dependent in humans and required functional angiotensin II …
Researchers found abnormal mitochondrial function in patients with geographic atrophy (a blinding eye disease) by analyzing fluid from inside the eye. In a small early-stage trial, oral alpha-ketoglutarate supplementation successfully increased the compound's levels in …
Tauopathies are neurodegenerative diseases characterized by the presence of hyperphosphorylated tau (p-tau) and neurofibrillary tangles. Autophagy is a critical self-degradation mechanism that preserves cellular homeostasis and function, including the clearance of misfolded proteins. Autophagy is …
This review paper synthesizes what we know about why people in five Blue Zone regions (Okinawa, Sardinia, Nicoya Peninsula, Ikaria, Loma Linda) live exceptionally long lives with low heart disease rates. The authors propose that …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
This review examines how immunosenescence (age-related immune decline) drives lung diseases like COPD, fibrosis, and cancer, and surveys emerging treatments including senolytics, stem cell therapy, and lifestyle interventions. While it synthesizes current knowledge well, it's …
INTRODUCTION: This study evaluates a novel lidocaine-premixed hyaluronic acid (HA) gel for nasolabial fold (NLF) correction, addressing pain management and longevity challenges in facial rejuvenation. The aim is to assess the non-inferiority, efficacy, and safety …
Frailty, a syndrome that decreases healthspan in older individuals, lacks effective therapies. We conducted a randomized, dose-finding clinical trial to test whether human bone marrow-derived allogeneic mesenchymal stem cells (MSCs; laromestrocel) improve physical functioning and …
Radiotherapy-induced skin fibrosis is a chronic progressive complication of radiotherapy that impairs function, aesthetics, and quality of life yet remains under-recognized and undertreated. While acute cutaneous toxicities are typically transient, chronic sequelae such as fibrosis, …
Researchers studied 3,703 adults over 90 and 22,354 younger adults to identify genetic variants linked not just to living longer, but to living longer *well*. They found that certain genes (APOE, APOC1) are associated with …
Heterochronic parabiosis improves physiological and cognitive function in aging rodents; these benefits appear to be derived from the removal of aged blood plasma components and the addition of younger ones. In humans, removing plasma from …
PURPOSE: To clinically evaluate dermal thickness, pores, and wrinkles after using Profhilo® in perioral regions. MATERIALS AND METHODS: This split-face study included 12 female participants aged 45 to 65 with visible signs of perioral aging. …
Almost a century ago, calorie restriction (CR) was identified as a robust intervention for extending lifespan and healthspan, a discovery that captured the imagination of both scientists and the public. If the powerful mechanisms engaged …
BACKGROUND: Deep-plane facelift (DPF) and its extended modification (EDPF) have been developed to address age-related changes in the lower face, particularly marionette lines, jowls, and neck laxity. Although both techniques provide durable rejuvenation, direct comparative …
The Bacillus Calmette-Guérin (BCG) vaccine, a live-attenuated derivative of Mycobacterium bovis, has long been central to global tuberculosis prevention. Although it protects well against severe childhood TB, its efficacy against adult pulmonary TB is variable. …
OBJECTIVE: To evaluate the effectiveness of high-frequency microneedling (HFM) using a layering technique versus conventional HFM for facial rejuvenation, with the Fitzpatrick Wrinkle and Laxity Classification Scale (FWCS) score at 3 months post-treatment as the …
BACKGROUND: Current barriers to achieving radical life extension include the inability to use syngeneic, youthful mesenchymal stem cells (MSCs) and the anti-regenerative effects of senescence-associated secretory phenotype (SASP) factors. We aim to overcome this by …
BACKGROUND: The 755-nm picosecond alexandrite laser with a diffractive lens array effectively treats photoaging in Asian patients but may cause transient adverse effects due to temporary disruption of the skin barrier. OBJECTIVE: This study evaluated …