Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans
BACKGROUND: Short-neck morphology remains a challenging problem in cervicofacial rejuvenation because conventional neck contouring techniques do not consistently improve neck length perception. OBJECTIVES: To evaluate a dual-plane deep reduction neck lift combining complete platysma transection …
PURPOSE: Aberrant enhancer dynamics play a critical role in the initiation and progression of colorectal cancer (CRC), particularly in the BRAFV600E-mutated metastatic subtype, which uniquely exhibits a strong epigenetic phenotype. Building on this epigenetic vulnerability, …
Aging is associated with declining mitochondrial function and translational regulation-processes modulated by interventions such as dietary restriction (DR) and cold-induced longevity (CHIL). Both DR and CHIL inhibit global protein synthesis but selectively enhance translation of …
The nuclear pore complex (NPC) is the single gateway between the nucleus and the cytoplasm, and in healthy cells there is a size threshold for passive diffusion across the NPC. In aging and disease, the …
The mechanistic target of rapamycin complex 1 (mTORC1) serves as a central metabolic hub that integrates nutrient signals and orchestrates cellular metabolism to regulate many fundamental cell processes. While mTORC1 activation is known to occur …
The prevalence of major depressive disorder (MDD) is increasing globally, particularly among adolescents. Although gut-brain axis dysfunction has been implicated in adolescent depression, the mechanisms by which gut microbiota dysbiosis drives depressive behaviors and potential …
Background: mTOR signaling promotes cell growth and anabolic processes in all eukaryotes. Hyperactivation of mTOR signaling is associated with various cancers along with hepatocellular carcinoma (HCC). HCC is a highly lethal malignancy with multiple aetiologies …
BACKGROUND: The aging process of the face is characterized by dermal thinning, loss of elasticity, and wrinkle formation. Injection of autologous micrografts containing fibroblasts (Am-FBs) has emerged as a promising regenerative technique. OBJECTIVES: This trial …
The development of geroprotectors, compounds that slow the biological aging process, is an important goal in modern medicine. These interventions hold the promise not only of extending lifespan, but more importantly, of extending healthspan-the period …
Motor Neurone Disease (MND) is characterised by progressive degeneration of upper and lower motor neurons, accompanied by cytoplasmic mislocalisation and hyperphosphorylation of TDP-43, hallmarks that implicate failure of endolysosomal proteostasis. The Endosomal Sorting Complexes Required …
Polycystic ovary syndrome (PCOS) is a highly heterogeneous endocrine-metabolic disorder whose core pathological features-follicular atresia and ovulatory dysfunction-are attributed to functional failure of ovarian granulosa cells (GCs). Although autophagy (a cellular quality-control mechanism) and ferroptosis …
A small clinical trial found that bezisterim, an experimental anti-inflammatory drug, reduced epigenetic markers of aging and was associated with changes in genes linked to brain inflammation and cognitive decline. However, this is early-stage work …
BACKGROUND: The E3 ubiquitin ligase CHIP/STUB1 is a known tumor suppressor in colorectal cancer (CRC) and other malignancies, but its mechanistic role in metabolic reprogramming remains elusive. This study aimed to elucidate whether CHIP regulates …
Autologous platelet-rich plasma (PRP) regenerative properties are used to treat clinical manifestations of skin aging. This study assessed the efficacy and safety of photothermal biomodulated PRP (PTBM-PRP) compared to standard PRP for skin rejuvenation. Prospective, …
Psoriasis is a chronic, immune-mediated dermatological disorder characterized by hyperproliferation of keratinocytes and dysregulated immune signaling. Although genome-wide association studies (GWAS) have identified susceptibility loci, the disease's multifactorial nature underscores the importance of non-genetic regulatory …
The VACS 2.0 Frailty Index was developed using the VA health records system to identify frailty and predict mortality in older Veterans that were living with HIV. Systemic inflammatory indices have been associated with frailty, …
Autophagy is a major intracellular degradative process required for maintaining homeostasis in multicellular organisms. Aberrant autophagy is considered to induce internal environmental disturbance and cell death. Therefore, it is of great significance to explore the …
Relapse in cancer is often driven by disseminated tumor cells (DTCs) that enter a dormant, non-proliferative state and later reactivate. Conventional pharmacology primarily focuses on eradicating dividing cells but lacks tools to induce and maintain …
INTRODUCTION: Outcome measurement in aesthetic medicine is complicated by subjective definitions of beauty, psychosocial factors, and a lack of standardized assessment metrics. Outcome reporting heterogeneity limits physicians' ability to synthesize results from multiple studies. The …
Telomere biology disorders (TBDs) are characterized by bone marrow failure (BMF) and dysfunctional telomeres. So far, inherited mutations in 18 genes have been identified in TBDs. Here, we describe a child presenting with early BMF, …