PVT1 lincRNA signals an androgen-dependent transcriptional activation program of oncogenes in prostate cancer cells.

Prostate cancer is the most prevalent malignancy among men and is driven by multiple factors, including androgen signaling and its receptor. Long non-coding RNAs, such as PVT1, play key roles in cancer, particularly by regulating …

38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10

Dectin-1 epigenetic reprogramming rescues senescent-like Treg function in allergic asthma.

Allergic asthma is characterized by immune dysregulation, and deficiencies in regulatory T-cell (Treg) function are a hallmark of the disease. However, mechanisms of Treg impairment for their therapeutic correction remain poorly defined. The results showed …

46 Early
Design 5
Sample 7
Peer Review 18
Replication 6
Transparency 10

Epigenetic and Transcriptional Regulatory Networks Underlying Psoriasis Pathogenesis.

Psoriasis is a chronic, immune-mediated dermatological disorder characterized by hyperproliferation of keratinocytes and dysregulated immune signaling. Although genome-wide association studies (GWAS) have identified susceptibility loci, the disease's multifactorial nature underscores the importance of non-genetic regulatory …

38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10