Computational simulations of human aging for intervention testing
To address challenges in fruit preservation, a sprayable hydrogel with aggregation-induced emission (AIE) activity was developed through the self-assembly of glycyrrhizic acid (GA) and berberine (BBR). Its formation mechanism and microstructure were elucidated by rheology, …
BACKGROUND: Platysmal bands are among the most visible signs of cervical ageing, commonly attributed to focal isometric contraction zones requiring targeted chemodenervation. However, this paradigm is based primarily on indirect imaging and clinical observation, with …
BACKGROUND: Non-ablative radiofrequency (RF) skin rejuvenation relies on controlled volumetric heating of skin and subcutaneous tissues. Clinical validation is costly and ethically constrained, while simulations require experimental validation. Existing single-layer phantoms cannot capture electrothermal heterogeneities …
Skin aging results from the synergistic assault of extrinsic environmental factors and intrinsic biological processes. While traditional microsphere implants promote skin rejuvenation through collagen regeneration, their clinical utility is hampered by non-biodegradability and risks such …
Background: Despite epidemiological interest in aspirin's chemopreventive potential against glioma, the underlying multilayered molecular mechanisms spanning gut microbial ecology, COX-2/PGE2 signaling, inter-organ iron homeostasis via the NEO1/hepcidin regulatory axis, epigenetic reprogramming, and ferroptosis have not …
The mechanistic target of rapamycin (mTOR) sits at the center of several cellular pathways determining cell growth, function, and stress adaptation. Dysregulated mTOR signaling contributes to aging-related diseases and cancer, making mTOR inhibitors an important …
Researchers conducted an intensive year-long self-study (N=1) combining time-restricted eating, exercise, Mediterranean diet, and continuous biomarker monitoring to assess how well a healthy person's body adapts to stress. The study demonstrates new methods for tracking …
Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …
The physicochemical degradation of asphalt during long-term service leads to pronounced aging, characterized by increased molecular aggregation, elevated viscosity, and degraded mechanical performance. Ultrasonic treatment has shown potential for reducing the viscosity of heavy oils …
The rising incidence of neurodegenerative disorders linked to protein fibrillation in aging populations highlights the need for efficient, low-toxicity fibrillation inhibitors. Quercetin, a natural flavonoid, shows potential in both suppressing fibrillation and disaggregating mature fibrils. …
Bisdemethoxycurcumin (BDMC) is a natural curcuminoid with higher solubility and stability than curcumin, yet its potential role in lifespan and healthspan regulation remains largely unexplored. This study aimed to investigate the effects of BDMC on …
Researchers used artificial intelligence to analyze 70,000 MRI scans and found that medical imaging can detect which organs are aging faster than normal—and these patterns correlate with diseases like MS and COPD, plus lifestyle factors …
Researchers built a computer simulation of how aging works in the body and tested which combination of four existing drugs (semaglutide, SGLT2 inhibitors, metformin, and rapamycin) might slow aging most effectively. The model suggests that …
Quantifying biological aging is crucial for understanding functional decline before the onset of morbidity. While many accelerated aging and frailty measures based on clinical data exist for humans and several for rodent models of aging, …
Apigenin nanocrystals (AN) were synthesized through supramolecular self-assembly and incorporated into a pectin/tamarind gum (PTG) matrix to fabricate edible bio-based nanocomposite films. Scanning electron microscopy (SEM) confirmed that AN exhibits a rod-like nanostructure. Both simulations …
Longevity medicine is transforming healthcare by shifting the focus from disease treatment toward the preservation of function, resilience, and healthspan. In parallel, artificial intelligence (AI) has emerged as a powerful catalyst accelerating this transition through …
Bio-oil is derived from a diverse range of feedstocks with significant differences in fatty acid form (FAF) and unsaturation (FAU), driven by its inherent compositional diversity. However, existing studies often show deviations in the selection …
Inflammatory bowel diseases (IBD) remain a relapsing, treatment-refractory disorder marked by progressive tissue injury and inflammation despite expanding immune-targeted therapies. We established a prospective cohort integrating stromal biobanking, functional phenotyping, cross-cohort benchmarking, and outcome modeling …
The clinical utility of nanobodies in solid tumor therapy is constrained by a fundamental biophysical trade-off: rapid renal clearance necessitates half-life extension, which in turn demands ultrahigh affinity to prevent dissociation from the target under …
CONTEXT: Feline Hypertrophic Cardiomyopathy (HCM) is a significant health issue, with a current prevalence of 14.7% in cats. The mammalian target of rapamycin (mTOR) is an atypical serine/threonine protein kinase system that also participates in …