Machine learning in aging, drug discovery, protein folding, and digital twins
The human cerebellum plays a central role in motor, emotional, and cognitive functions, and is implicated in many brain disorders. To improve the analysis of functional and anatomical imaging from the cerebellum, we introduce SUITPy, …
INTRODUCTION: Increased global lifespan is paralleled by a rise in non-communicable diseases with osteoarthritis and dementia, including Alzheimer's disease, impacting all nations with severe disability, death, and financial burden. AREAS COVERED: Given that osteoarthritis and …
In modern dairy systems, sustained milk production over the lifetime of a cow depends critically on maintaining reproductive efficiency across repeated lactation cycles. However, repeated lactation and advancing parity impose cumulative metabolic and inflammatory stress …
Researchers built a computer simulation of how aging works in the body and tested which combination of four existing drugs (semaglutide, SGLT2 inhibitors, metformin, and rapamycin) might slow aging most effectively. The model suggests that …
Aging leads to structural changes in facial adipose tissue, characterized by an imbalance between adipocyte regeneration and hypertrophy. Current therapeutic approaches primarily target individual aspects of these changes, often failing to address the dual nature …
Bone aging is not merely a process of bone mass loss but rather a multi-level, networked degenerative phenomenon spanning molecular, cellular, tissue, and system levels. With the accelerating pace of global population aging, bone degenerative …
Mitochondria support the bioenergetic processes that enable brain function and cognition, but we have lacked a label-free, non-invasive approach to explore how brain mitochondria are linked to ageing, disease, and cognition in humans. A recently …
Biological age describes how a person is aging on molecular, cellular, and physiological levels. At the present time, biological age is not something that can be fully quantified and aging itself is far too complicated …
Selective photothermolysis, which enables precise targeting of melanin, hemoglobin, and water, is the foundation for modern dermatologic laser therapy. This review bridges laser physics with clinical practice by organizing systems on the basis of spectral …
BACKGROUND: The clinical efficacy of osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), in EGFR-mutant non-small cell lung cancer (NSCLC) is limited by the inevitable acquired resistance. Drug-tolerant persister (DTP) cells, …
UNLABELLED: Heat stress significantly disrupts physiological and molecular balance in poultry, leading to oxidative damage, inflammatory responses, and metabolic dysregulation. Among emerging solutions, phytogenic adaptogens have shown promise as natural agents that enhance resilience against …
Aging emerges from nonlinear interactions among primary, antagonistic, and integrative hallmarks that progressively erode tissue resilience. As global demographics shift and chronic disease burden intensifies, extending healthspan with mechanistic precision has become imperative, accelerating the …
Chronological age incompletely captures heterogeneity in biological aging. In this prospective study of 45,819 UK Biobank participants, we developed a multimodal ocular aging index (MOAI) by integrating ophthalmic phenotypes with plasma proteomic and metabolomic profiles …
Tissue structure, the organization of cells, vasculature and extracellular matrix, underpins organ function. Yet how it deteriorates with age remains largely uncharacterized. Current aging research focuses primarily on molecular changes, missing this structural dimension. Here …
Telomere Biology Disorders (TBDs) are a genetically heterogeneous and often under-recognized cause of Bone Marrow Failure Syndromes (BMFS), driven by defective telomere maintenance and progressive telomere attrition. We performed an integrated genomic, telomeric and computational …
Treatment effectiveness is hindered by the phenotypic plasticity of cancer and the genetic complexity of tumors. However, CRISPR-Cas-based medicines face challenges with specificity, off-target effects, and tumor heterogeneity adaptability. This work investigates the possible combination …
BACKGROUND: Facelift and necklift remain the gold standard for surgical facial rejuvenation despite continued advances in nonsurgical aesthetic treatments. Modern facial rejuvenation has evolved beyond simple skin excision to restore youthful facial proportions through the …
Researchers created LongevityBench, a standardized test to evaluate whether large language models (LLMs) can accurately interpret aging biology and predict age-related outcomes from biodata. The benchmark spans human lifespan prediction, genetic effects, and multiple data …
Extra villous trophoblasts (EVTs) dysfunction impairing spiral artery remodeling (SAR) is a key preeclampsia (PE) factor. ScRNA-seq and bioinformatics analyses of preeclamptic placentas revealed the upregulation of TET3, a newly recognized regulator of epigenetic reprogramming. …
AIMS AND BACKGROUNDS: The objectives of this study are to examine the emerging role of personalized medicine in facial plastic surgery and to consider how biologically, anatomically, and psychologically tailored approaches may refine both aesthetic …