Drug Discovery — OutliveHub

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Two Repurposed Drugs Trigger Cellular Stress Responses That Extend Lifespan in Worms

Two common drugs might slow aging by triggering cells' defense systems—but we need to test this claim in humans first.

Researchers found that terbinafine (an antifungal) and miglustat (a diabetes drug) activate mitochondrial stress responses that extended lifespan and improved health markers in C. elegans worms and human cells. The discovery suggests these existing drugs …

Aging cell

44 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

Ginsenoside Rg1 delays chronological aging in a yeast model via SSE1-Mediated mitophagy.

Ginsenoside Rg1 (Rg1), an active compound in Panax ginseng C. A. Meyer (ginseng), has shown potential to ameliorate age-related cell damage and extend lifespan in multiple model organisms. However, the precise molecular mechanisms of its …

Gene

46 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Bisdemethoxycurcumin extends lifespan and healthspan in Caenorhabditis elegans via modulation of EGFR-linked signaling pathways.

Bisdemethoxycurcumin (BDMC) is a natural curcuminoid with higher solubility and stability than curcumin, yet its potential role in lifespan and healthspan regulation remains largely unexplored. This study aimed to investigate the effects of BDMC on …

Food & function

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Atractylenolide I ameliorates acute-on-chronic liver failure (ACLF) by promoting autophagy and preserving mitochondrial function through mTOR inhibition.

Acute-on-chronic liver failure (ACLF) is a severe liver syndrome marked by systemic inflammation and high mortality, often complicated by autophagy impairment and mitochondrial dysfunction. This study investigates atractylenolide I (AT-1), a compound from Atractylodes macrocephala, …

Biochimica et biophysica acta. Molecular basis of disease

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other bioRxiv

Single-dose rapamycin increases brain glucose metabolism but reduces synaptic density in Long-Evans rats

Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), has shown promise as a neuroprotective compound in preclinical studies. Reduced brain glucose metabolism and loss of synaptic density are key features of Alzheimer's disease …

biorxiv (preprint)

39 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Peptides in facial plastic surgery: emerging applications in aesthetics and rejuvenation.

Bioactive peptides have become increasingly common ingredients in skincare products and procedural adjuncts in aesthetic practices. Modeled after naturally occurring matrikines, these short amino acid chains are designed to influence the extracellular matrix (ECM), cellular …

Facial plastic surgery : FPS

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice.

The Interventions Testing Program (ITP) evaluated eleven compounds in genetically heterogeneous UM-HET3 mice to assess their potential to extend lifespan. These interventions included both novel agents and previously tested compounds administered at novel doses or …

GeroScience

44 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … In Vitro PubMed

Natural compound DMB reduces cellular aging by activating DNA repair protein FEN1

Researchers found that demethyleneberberine (DMB), a natural compound from tree bark, can reverse signs of cellular aging in human fibroblasts and extend lifespan in C. elegans by activating a DNA repair enzyme called FEN1. While …

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

36 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Some Anti-Aging Compounds Extend Male Worm Lifespan, But Not Always Reproductive Health

Researchers tested seven compounds known to slow aging in hermaphrodite worms on male worms and found that all extended lifespan, but only sulforaphane and metformin improved reproductive function in older males. This suggests that living …

GeroScience

43 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … In Vitro PubMed

A Plant Compound Delays Aging in Cells by Activating Stress-Defense Pathways

Researchers found that 3,5-dicaffeoylquinic acid (3,5-diCQA), a compound from plants, delayed aging and improved stress resistance in worms and human cells by activating a well-known cellular defense pathway called SKN-1/Nrf2. The compound appears to work …

Food science & nutrition

40 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

A Fungal Compound Protects Worm Brains from Amyloid Damage by Boosting Cellular Cleanup

Researchers found that chaetoglobosin F, a compound from fungi, protected genetically engineered worms from amyloid-beta toxicity by enhancing autophagy (cellular cleanup) and reducing oxidative damage. While promising in this model system, the work is still …

Neurochemical research

40 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins In Vitro PubMed

How a NAD+ mimic activates the aging-linked SIR2 protein through internal communication networks

Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …

PLoS computational biology

41 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

A new compound that extends the lifespan of worms, with favorable in vitro properties and a lack of toxicity in rodents.

The development of geroprotectors, compounds that slow the biological aging process, is an important goal in modern medicine. These interventions hold the promise not only of extending lifespan, but more importantly, of extending healthspan-the period …

RSC medicinal chemistry

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Interactions of anthocyanidin compounds (ANCs) with nutrients in food: A review.

Anthocyanidin compounds (ANCs), a class of flavonoids, are natural plant pigments that have become a hot research topic in food science because of their diverse bioactivities. This article provides an overview of the forms of …

Food research international (Ottawa, Ont.)

38 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other bioRxiv

A role for autophagy of the ER in rejuvenation revealed by microfluidics-based lifespan profiling of yeast gametes

During mitotic growth, Saccharomyces cerevisiae cells age by dividing asymmetrically producing young daughter cells while retaining age-associated damage in the mother cell, which will eventually become senescent. Gametogenesis naturally and completely resets precursor cell lifespan, …

biorxiv (preprint)

34 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Optimization of sonication for preserving the biochemical and physicochemical attributes of pomegranate arils during storage.

Pomegranate arils rapidly experience quality deterioration and a decline in bioactive compounds during storage. This study aimed to develop and optimize an effective non-thermal technology by evaluating the efficacy of ultrasound treatment in preserving the …

Ultrasonics sonochemistry

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Iridoids from the edible flowers of Rhododendron pachypodum: structural elucidation and healthspan related bioactivities in Caenorhabditis elegans.

Rhododendron pachypodum flowers are traditionally consumed by ethnic minorities in Yunnan as seasonal edible flowers, yet their bioactive iridoid constituents and associated biological activities remain underexplored. This study characterized the iridoid constituents and evaluated in …

Phytochemistry

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

An Updated Narrative Review on the Therapeutic Potential of Resveratrol in the Treatment of Cancer.

BACKGROUND: Cancer is a significant global health challenge, affecting millions of people every year. Overall survival rates have improved over time, but some patients exhibit treatment resistance, prompting ongoing research to find suitable and effective …

Health science reports

46 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Epigenetic Regulation Links Bacterial Signaling to Growth and Reproductive Development in the Green Macroalga Ulva compressa (Chlorophyta).

UNLABELLED: DNA (deoxyribonucleic acid) methylation is a key epigenetic mechanism that regulates gene expression and developmental transitions in eukaryotes. Interestingly, algal growth- and morphogenesis-promoting bacteria can reduce global DNA methylation levels in the green seaweed …

Marine biotechnology (New York, N.Y.)

38 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other medRxiv

Anopheles salivary antibody biomarkers as surrogate outcomes measures to assess the effectiveness of topical repellent in Southeast Myanmar

Background Measurement of human antibodies against Anopheles salivary proteins that are injected during mosquito bites may serve as biomarkers of mosquito biting exposure. These biomarkers have been suggested as surrogate outcomes in trials of vector …

medrxiv (preprint)

34 Early