Drug Discovery — OutliveHub

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How worm mitochondria adapt to stress and live longer

Mild stress on cellular power plants may trigger protective cleanup systems that extend lifespan, a mechanism conserved across species.

This review examines how C. elegans worms switch their mitochondrial energy-production machinery to survive low-oxygen or toxic conditions, and how mild damage to this system can actually extend lifespan. The findings suggest conserved cellular stress-response …

Experimental cell research

41 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Crop Resilience to Combined Drought and Salinity Stress in Drylands: From Soil Processes to Genomic Solutions.

Drought and soil salinization increasingly co‑occur, threatening global food security, particularly in dryland farming systems where these stresses can interact additively, synergistically or antagonistically to reduce crop yields. This review critically distinguishes these interaction types …

Plant, cell & environment

46 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Advances in Cyclic Peptides Targeting G Protein-Coupled Receptors.

Peptide-responsive G protein-coupled receptors (GPCRs) often recognize endogenous peptide ligands through extended receptor interfaces, providing opportunities for peptide-based ligands to engage receptor contacts that conventional small molecules struggle to access effectively. In this context, cyclic …

Chembiochem : a European journal of chemical biology

38 Early

Promising Biomarkers — Aging clocks and measurement tools Cohort Study PubMed

What Slows (and Speeds) Skin Aging at the DNA Level

Identifies everyday habits and drugs linked to skin aging, offering new targets to test—but doesn't yet prove any slow aging.

Researchers analyzed DNA methylation patterns in 851 people and found 37 lifestyle, health, and drug factors linked to skin aging—some slowing it down, others speeding it up. Compounds like aspirin and dihydromyricetin showed associations with …

Clinical epigenetics

57 Promising

Preliminary Cellular — Research on cellular-level aging mechanisms Other bioRxiv

A role for autophagy of the ER in rejuvenation revealed by microfluidics-based lifespan profiling of yeast gametes

During mitotic growth, Saccharomyces cerevisiae cells age by dividing asymmetrically producing young daughter cells while retaining age-associated damage in the mother cell, which will eventually become senescent. Gametogenesis naturally and completely resets precursor cell lifespan, …

biorxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

A derivative of cytisine N-isoflavone from Sophora alopecuroides L., suppresses non-small cell lung cancer by targeting mTOR.

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, highlighting the urgent requirement for innovative therapeutic strategies. Cytisine N-methylene-(4',5,7-trihydroxy)-isoflavone (named CNI3), a natural derivative of cytisine N-isoflavone isolated from Sophora alopecuroides …

European journal of pharmacology

38 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model PubMed

Can the smell of toasted bread slow aging? C. elegans study suggests yes

Smelling food aromas might activate anti-aging pathways in cells, but we don't know if this works in humans yet.

Researchers exposed C. elegans worms to odors from the Maillard reaction (the browning that happens when food is cooked) and found it extended lifespan, improved movement, and boosted stress resistance—effects that depended on activating a …

Bioscience, biotechnology, and biochemistry

40 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Exposure, fate and impact of food preservatives in the environment.

Food preservatives and preservative-related additives support food safety and shelf-life extension, but their environmental relevance depends on compound-specific release pathways, transformation behaviour, and receiving compartments. This structured narrative review synthesises evidence on the environmental exposure, …

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan.

Organs age at different rates, yet the protective mechanisms contributing to decelerated aging in certain tissues remain unclear. Applying cross-tissue comparisons to molecular readouts of aging, here we report that the intervertebral disc (IVD) ages …

Nature aging

47 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Phytochemicals modulating HSF-1-associated pathways: A systematic review of longevity-extending mechanisms in Caenorhabditis elegans.

Aging is characterized by progressive loss of proteostasis, and heat shock transcription factor 1 (HSF1) is the master regulator of the cellular stress response, making it an attractive pharmacological target for interventions aimed at extending …

Ageing research reviews

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other bioRxiv

Senescent cells are more susceptible to reductive stress-induced cell death: implications for senolytic research.

Proliferating cells can enter an irreversible state of cell-cycle arrest known as cellular senescence. The accumulation of senescent cells contributes to organismal ageing and age-related pathologies. Consequently, therapeutic strategies have emerged to selectively eliminate senescent …

biorxiv (preprint)

34 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How Replacing Damaged Cells and Tissues Could Reverse Aging

Scientists propose strategies to repair and replace damaged body parts to reverse aging, rather than just slow it down.

This perspective paper proposes that replacing damaged cellular and tissue components—rather than just slowing aging—could reverse age-related decline and extend healthy lifespan. Leading longevity researchers outline a roadmap for developing these 'replacement-based' therapies and combining …

Aging cell

34 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Atractylenolide I ameliorates acute-on-chronic liver failure (ACLF) by promoting autophagy and preserving mitochondrial function through mTOR inhibition.

Acute-on-chronic liver failure (ACLF) is a severe liver syndrome marked by systemic inflammation and high mortality, often complicated by autophagy impairment and mitochondrial dysfunction. This study investigates atractylenolide I (AT-1), a compound from Atractylodes macrocephala, …

Biochimica et biophysica acta. Molecular basis of disease

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

NAD⁺ biology and supplementation: From mechanisms to clinical perspectives.

This study examines the biological and clinical relevance of NAD⁺ supplementation using a combined review and mathematical modelling approach. NAD⁺ plays a central role in cellular energy metabolism, redox balance, and signaling pathways linked to …

Molecular biology reports

38 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins In Vitro PubMed

How a NAD+ mimic activates the aging-linked SIR2 protein through internal communication networks

Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …

PLoS computational biology

41 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Bisdemethoxycurcumin extends lifespan and healthspan in Caenorhabditis elegans via modulation of EGFR-linked signaling pathways.

Bisdemethoxycurcumin (BDMC) is a natural curcuminoid with higher solubility and stability than curcumin, yet its potential role in lifespan and healthspan regulation remains largely unexplored. This study aimed to investigate the effects of BDMC on …

Food & function

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary PubMed

Can ginseng compounds slow aging? A review of the science and future potential

Ginseng compounds show promise against aging in lab tests, but we lack proof they work in real people yet.

This review examines ginsenosides—compounds from ginseng—and their potential anti-aging effects through mechanisms like reducing cellular stress and supporting mitochondrial health. While promising in laboratory studies, the authors emphasize that moving from bench science to functional …

Critical reviews in food science and nutrition

35 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary PubMed

How Metformin May Slow Aging: Mechanisms and Evidence

Metformin, a cheap diabetes drug, might slow aging, but we need stronger proof before recommending it to everyone.

This review examines how metformin, a common diabetes drug, may have anti-aging properties by activating cellular stress-response pathways (AMPK), reducing inflammation, and improving mitochondrial function. While observational studies and mechanistic evidence are promising, the authors …

Molecular and cellular endocrinology

40 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Neuropathic pain in traumatic brain injury: consequences, mechanisms, and therapeutic avenues.

Traumatic brain injury (TBI) is a global health crisis affecting approximately 27 million individuals annually. Nearly half of TBI survivors develop chronic neuropathic pain, with post-traumatic headache representing the most prevalent pain syndrome. Despite substantial …

Inflammopharmacology

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Iridoids from the edible flowers of Rhododendron pachypodum: structural elucidation and healthspan related bioactivities in Caenorhabditis elegans.

Rhododendron pachypodum flowers are traditionally consumed by ethnic minorities in Yunnan as seasonal edible flowers, yet their bioactive iridoid constituents and associated biological activities remain underexplored. This study characterized the iridoid constituents and evaluated in …

Phytochemistry

38 Early