Computational approaches to discovering geroprotective compounds
Aging emerges from nonlinear interactions among primary, antagonistic, and integrative hallmarks that progressively erode tissue resilience. As global demographics shift and chronic disease burden intensifies, extending healthspan with mechanistic precision has become imperative, accelerating the …
This review examines how C. elegans worms switch their mitochondrial energy-production machinery to survive low-oxygen or toxic conditions, and how mild damage to this system can actually extend lifespan. The findings suggest conserved cellular stress-response …
Researchers analyzed DNA methylation patterns in 851 people and found 37 lifestyle, health, and drug factors linked to skin aging—some slowing it down, others speeding it up. Compounds like aspirin and dihydromyricetin showed associations with …
Ginsenoside Rg1 (Rg1), an active compound in Panax ginseng C. A. Meyer (ginseng), has shown potential to ameliorate age-related cell damage and extend lifespan in multiple model organisms. However, the precise molecular mechanisms of its …
During mitotic growth, Saccharomyces cerevisiae cells age by dividing asymmetrically producing young daughter cells while retaining age-associated damage in the mother cell, which will eventually become senescent. Gametogenesis naturally and completely resets precursor cell lifespan, …
Bioactive peptides have become increasingly common ingredients in skincare products and procedural adjuncts in aesthetic practices. Modeled after naturally occurring matrikines, these short amino acid chains are designed to influence the extracellular matrix (ECM), cellular …
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, highlighting the urgent requirement for innovative therapeutic strategies. Cytisine N-methylene-(4',5,7-trihydroxy)-isoflavone (named CNI3), a natural derivative of cytisine N-isoflavone isolated from Sophora alopecuroides …
Researchers found that terbinafine (an antifungal) and miglustat (a diabetes drug) activate mitochondrial stress responses that extended lifespan and improved health markers in C. elegans worms and human cells. The discovery suggests these existing drugs …
Researchers found that Dendrobium officinale, a traditional longevity herb, extended lifespan in yeast and fruit flies by modulating a key aging-control pathway called PI3K-AKT. Different parts of the plant worked in opposite ways depending on …
Researchers exposed C. elegans worms to odors from the Maillard reaction (the browning that happens when food is cooked) and found it extended lifespan, improved movement, and boosted stress resistance—effects that depended on activating a …
Growing consumer demand for clean-label and antibiotic-free meat products has intensified interest in plant-based bioactive compounds as next-generation antimicrobials. This review synthesizes current knowledge on the key phytochemicals essential oils, phenolics, terpenoids, alkaloids, and flavonoids …
Researchers developed an improved method (FAβ-gal) to detect and quantify senescent cells—aging cells that stop dividing—using existing lab equipment. The new approach is faster, more accurate, and less subjective than the current gold-standard test, potentially …
Taurine is a non-proteinogenic β-amino acid that plays fundamental roles in cellular homeostasis. Although it is the most abundant free amino acid in many tissues, the full spectrum of its molecular functions has only recently …
Organs age at different rates, yet the protective mechanisms contributing to decelerated aging in certain tissues remain unclear. Applying cross-tissue comparisons to molecular readouts of aging, here we report that the intervertebral disc (IVD) ages …
Researchers found that a natural compound from peanuts (procyanidin A) can rejuvenate aging blood stem cells in mice by reducing cellular stress and shifting their metabolism. The compound worked by targeting a specific mitochondrial protein …
Aging is characterized by progressive loss of proteostasis, and heat shock transcription factor 1 (HSF1) is the master regulator of the cellular stress response, making it an attractive pharmacological target for interventions aimed at extending …
Proliferating cells can enter an irreversible state of cell-cycle arrest known as cellular senescence. The accumulation of senescent cells contributes to organismal ageing and age-related pathologies. Consequently, therapeutic strategies have emerged to selectively eliminate senescent …
The mechanistic target of rapamycin (mTOR) sits at the center of several cellular pathways determining cell growth, function, and stress adaptation. Dysregulated mTOR signaling contributes to aging-related diseases and cancer, making mTOR inhibitors an important …
This perspective paper proposes that replacing damaged cellular and tissue components—rather than just slowing aging—could reverse age-related decline and extend healthy lifespan. Leading longevity researchers outline a roadmap for developing these 'replacement-based' therapies and combining …
Acute-on-chronic liver failure (ACLF) is a severe liver syndrome marked by systemic inflammation and high mortality, often complicated by autophagy impairment and mitochondrial dysfunction. This study investigates atractylenolide I (AT-1), a compound from Atractylodes macrocephala, …