Epigenetics

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Other bioRxiv

How Calorie Restriction Quiets Immune Attacks on Aging Pancreas Cells

A new clue about why pancreas cells fail during aging and diabetes—and evidence calorie restriction might reverse this in mice.

Researchers discovered that aging pancreas alpha cells trigger inflammatory immune responses linked to type 2 diabetes. In mice, calorie restriction reversed this inflammation by reducing immune cell recruitment to the pancreas. This suggests a new …

biorxiv (preprint)
26 Early
Design 6
Sample 6
Peer Review 3
Replication 5
Transparency 6
How we score →
Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Metformin at the convergence of aging and longevity.

Metformin is a biguanide and first line drug for type 2 diabetes (T2D) mellitus that is being recognized as a geroprotective agent capable of influencing important hallmarks of aging. Apart from its primary role in …

Aging
44 Early
Design 5
Sample 7
Peer Review 16
Replication 6
Transparency 10
How we score →
Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

The niche-metabolism axis: reprogramming tumor-associated macrophages for precision immunotherapy.

Tumor-associated macrophages (TAMs) critically modulate solid tumor progression and immunotherapy resistance, yet their profound context-dependent heterogeneity defies the traditional M1/M2 dichotomy. In this review, we propose the 'niche-metabolism axis' framework, deconstructing the tumor microenvironment into …

Trends in molecular medicine
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Epigenetic landscapes of classical psychedelics and ketamine: molecular mechanisms of long-lasting neuromodulation.

Classic psychedelics such as lysergic acid diethylamide (LSD), psilocybin, N,N-dimethyltryptamine (DMT), and mescaline induce lasting changes in neuroplasticity and behavior that extend far beyond their acute pharmacological effects. Emerging evidence highlights that these enduring therapeutic …

Molecular psychiatry
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

A Dual Approach to Glioblastoma Treatment with Epigenetic Reprogramming and Neurogenetic Modulation.

Glioblastoma is a highly aggressive primary brain tumour marked by extensive genomic and epigenomic alterations, cellular heterogeneity, and therapeutic resistance. Despite maximal surgical resection followed by chemoradiotherapy, median survival remains approximately 15 months, reflecting the …

Carcinogenesis
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

KDM4A-Driven Epigenetic Reprogramming as a Central Nexus Linking Metabolic Adaptation, Immune Remodeling, and Therapy Resistance in Cancer.

Cancer progression and treatment failure are driven not only by genetic alterations but also by the remarkable capacity of tumor cells to adapt to metabolic stress, immune surveillance, and therapeutic pressure. Epigenetic plasticity provides a …

Critical reviews in oncology/hematology
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Validating raloxifene-mediated restoration of DNMT-TET epigenetic balance in breast and lung cancer.

The aberrant DNA methylation is a characteristic feature of solid tumours, but the imbalance of DNA methyltransferases and demethylases has not been studied at the network level across breast and lung cancers. To determine the …

Cancer treatment and research communications
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Targeting metabolic reprogramming and epigenetic remodeling: a novel strategy to reshape the immune microenvironment in multiple myeloma.

Multiple myeloma (MM) is a highly debilitating hematologic malignancy with a significant risk of mortality, now entering an era of comprehensive treatment. However, immune resistance remains the primary obstacle limiting long-term survival and effective treatment …

International immunopharmacology
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Research progress on lactate metabolism in lung cancer: Tumorigenesis, drug resistance and clinical translation (Review).

Therapeutic resistance is the main obstacle to long‑term survival in lung cancer, with metabolic reprogramming identified as a key factor in this failure. Accumulating evidence suggests that metabolic reprogramming, particularly the aberrant metabolism of lactate, …

Oncology reports
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How Lysosomes Control Aging: New Pathways to Longer, Healthier Lives

Cells have recycling centers that control aging. Better recycling may slow getting older and prevent age-related diseases.

This review examines how lysosomes—cellular recycling centers—actively regulate aging through two newly discovered signaling pathways (lysosomal surveillance response and transgenerational lysosomal signaling) and the protein TFEB. These findings suggest targeting lysosomal activity could be a …

Ageing research reviews
35 Early
Design 4
Sample 2
Peer Review 13
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Trained immunity in monocytes and macrophages in atherosclerotic cardiovascular disease.

Monocytes and macrophages are critically involved in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Accumulating evidence indicates that monocytes and macrophages can develop innate immune memory and exhibit sustained pro-inflammatory properties in response to stimuli …

Cardiovascular research
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Accelerated epigenetic ageing in congenital heart disease: the AccelerAGE study.

BACKGROUND AND AIMS: Adults with congenital heart disease tend to develop both cardiac and noncardiac age-related comorbidities earlier in life than the general population, suggesting accelerated biological ageing. Epigenetic clocks estimate biological age based on …

European heart journal
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

To longevity and beyond: a systems view of aging and stress resilience.

Aging is a dynamic and time-dependent process characterized by progressive functional decline across biological systems. Key hallmarks, including genomic instability, telomere attrition, loss of proteostasis, mitochondrial dysfunction, and immunosenescence, have been widely described, each reflecting …

Mechanisms of ageing and development
44 Early
Design 5
Sample 7
Peer Review 16
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Fasting and Aging: Mechanistic Insights into Epigenomic and Transcriptional Regulation of Healthspan.

Fasting is an effective physiological intervention eliciting global and cellular adaptations that can improve healthspan and lifespan. In addition to its metabolic effects, fasting is a state of modulation of aging-associated processes/adaptive cellular responses that …

Mechanisms of ageing and development
44 Early
Design 5
Sample 7
Peer Review 16
Replication 6
Transparency 10
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Targeting tumor transition windows.

Tumor heterogeneity and cellular plasticity are major drivers of therapeutic failure across many cancer types. While precision oncology has largely focused on static genomic alterations, growing evidence indicates that tumors behave as dynamic biological systems …

Exploration of targeted anti-tumor therapy
43 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 15
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

WHO-Recommended Exercise Dose Is Associated With Slower Epigenetic Aging in Older Adults

The dose-response of six months of controlled exercise was studied in 72 subjects aged 50 to 70 years, with 1-4 training sessions per week, focusing on DNA methylation-based aging. Epigenetic age reduction increased with exercise …

medrxiv (preprint)
39 Early
Design 5
Sample 7
Peer Review 4
Replication 6
Transparency 17
How we score →
Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

Mathematical modeling of T cell exhaustion in the tumor microenvironment.

T cell exhaustion (TCE), a hallmark of chronic infections and cancer, is characterized by progressive loss of effector function, sustained expression of inhibitory receptors, and stable transcriptional/epigenetic reprogramming. Within the tumor microenvironment (TME), exhausted CD8+ …

Pharmacology & therapeutics
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms In Vitro PubMed

A Drug That Kills Aging Cells in Osteoarthritis Without Harming Healthy Ones

A candidate drug could selectively kill harmful aged cells in arthritic joints while protecting healthy ones—potentially opening a new treatment avenue.

Researchers found that mocetinostat, a drug that inhibits certain histone deacetylases, selectively kills senescent (aged) chondrocytes—cells that accumulate in arthritic joints—while leaving healthy cells intact. This discovery could lead to a new class of "senolytic" …

GeroScience
40 Early
Design 5
Sample 6
Peer Review 15
Replication 5
Transparency 9
How we score →
Promising Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Targeted Transcriptional Repression by Induced Proximity.

Many transcription factors are considered "undruggable" and challenging targets due to the absence of ligandable pockets, large swaths of intrinsically disordered regions, and rapid turnover. Here, we describe a new induced-proximity therapeutic modality, Transcriptional Repression …

ACS central science
51 Promising
Design 5
Sample 7
Peer Review 18
Replication 6
Transparency 15
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Pancreatic cancer EMT‑targeted therapy: Molecular mechanisms and clinical translation (Review).

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a dismal 5‑year survival rate of ~9%, primarily due to late diagnosis, aggressive metastasis and profound resistance to conventional therapies. Epithelial‑mesenchymal transition (EMT) …

International journal of oncology
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →