Geroprotectors — OutliveHub

Promising Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Can a longevity protein protect Parkinson's patients from memory loss?

A protein that naturally extends lifespan might protect Parkinson's patients' thinking and memory, pointing to new treatments.

A protein called klotho, known to extend lifespan and boost brain function, appears to protect people with Parkinson's disease from cognitive decline—at least in genetic studies and mouse models. Researchers found that higher klotho levels …

The Journal of neuroscience : the official journal of the Society for Neuroscience

53 Promising

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Randomised Controlled Trial medRxiv

Can bezisterim slow brain aging in Alzheimer's disease?

A small clinical trial found that bezisterim, an experimental anti-inflammatory drug, reduced epigenetic markers of aging and was associated with changes in genes linked to brain inflammation and cognitive decline. However, this is early-stage work …

medrxiv (preprint)

31 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

Plant extract Salvia plebeia triggers cellular cleanup and reverses aging signs in mice

Researchers found that an ethanol extract from Salvia plebeia plant enhanced autophagy (cellular garbage disposal) and reversed senescence markers in cell culture and aged mice, with rosmarinic acid identified as a key active ingredient. The …

The Journal of nutritional biochemistry

41 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

A Natural Plant Compound Slows Aging in Worms by Boosting Cellular Cleanup

Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …

Journal of ethnopharmacology

41 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

A new compound that extends the lifespan of worms, with favorable in vitro properties and a lack of toxicity in rodents.

The development of geroprotectors, compounds that slow the biological aging process, is an important goal in modern medicine. These interventions hold the promise not only of extending lifespan, but more importantly, of extending healthspan-the period …

RSC medicinal chemistry

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

No evidence for squaring the survival curve: lifespan-extending treatments increase variation in age- at-death.

Geroscience has the goal of extending lifespan through geroprotective interventions. These interventions are typically imparted on groups of individuals, with their efficacy judged by increases in the average age-at-death. A more equitable outcome, which looks …

Biology letters

38 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other bioRxiv

TranslAGE: A Comprehensive Platform for Systematic Validation of Epigenetic Aging Biomarkers

Epigenetic clocks are powerful biomarkers of biological aging, however, their performance varies across studies and contexts. Current limitations include siloed datasets, inconsistent validation methods, and the absence of a standardized framework for systematic comparison. Here, …

biorxiv (preprint)

34 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

No evidence lithium supplementation extends lifespan in male Drosophila melanogaster.

Pharmacological modulation of ageing is viewed as a viable route to extending lifespan and healthspan, yet the efficacy of putative geroprotectors may depend strongly on physiological and environmental context. Lithium chloride (LiCl) has been reported …

Biogerontology

44 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

Multi-modal and multi-organ in vivo imaging to assess geroprotective interventions in humans: results from a pilot trial of rapamycin in Alzheimer's Disease

BackgroundGeroprotective interventions, including the mTOR inhibitor rapamycin, slow aging in preclinical models. Translation to humans remains challenging because clinical trials require endpoints detectable within feasible timeframes. Multi-modal in vivo imaging could address this limitation by …

medrxiv (preprint)

34 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice.

The Interventions Testing Program (ITP) evaluated eleven compounds in genetically heterogeneous UM-HET3 mice to assess their potential to extend lifespan. These interventions included both novel agents and previously tested compounds administered at novel doses or …

GeroScience

44 Early

Preliminary Biomarkers — Aging clocks and measurement tools Observational PubMed

Gut Bacteria Linked to Living Past 90: What Their Microbiomes Reveal

Researchers compared gut bacteria in people aged 45–59, 60–89, and 90+ and found that centenarians have distinctly different microbial communities—richer in beneficial bacteria like Akkermansia and enriched in pathways that produce fatty acids and other …

Applied microbiology and biotechnology

44 Early

Promising Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Exercise's Brain-Boosting Molecule Reverses Memory Loss by Cleaning Up Blood Vessels

Researchers identified a liver-derived protein called GPLD1 that transfers exercise's cognitive benefits to the brain by targeting blood vessel dysfunction. In aging and Alzheimer's mouse models, boosting GPLD1 or blocking its downstream target TNAP restored …

Cell

59 Promising

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

Can Young Blood Make You Younger? What Science Actually Shows (and Doesn't)

This review examines whether infusing young plasma can rejuvenate aging bodies, a concept supported by animal experiments but largely unproven in humans. The authors argue that while preclinical models show promise, current clinical applications of …

GeroScience

41 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Observational PubMed

Does Ginseng Slow Aging? A Small Study on Telomeres and Cellular Energy in Middle-Aged Adults

Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores.

Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores. However, the study is very small, lacks …

Journal of ethnopharmacology Feb 15, 2026

41 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

New Drug Candidate 28i Shows Promise for Slowing Aging in Animal Models

Researchers engineered a new compound called 28i that inhibits an enzyme (MDH2) linked to aging, extending lifespan in worms and reducing aging markers in mouse cells and tissues.

Researchers engineered a new compound called 28i that inhibits an enzyme (MDH2) linked to aging, extending lifespan in worms and reducing aging markers in mouse cells and tissues. Unlike its parent drug, 28i avoids dangerous …

Journal of medicinal chemistry Feb 15, 2026

39 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

How to Reverse Age-Related Immune System Decline

This review examines why the thymus (a gland that produces immune cells) shrinks with age and stops making T cells effectively, leaving older adults vulnerable to infections and cancer.

This review examines why the thymus (a gland that produces immune cells) shrinks with age and stops making T cells effectively, leaving older adults vulnerable to infections and cancer. The authors survey promising rejuvenation strategies—from …

Science advances Feb 15, 2026

40 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How aging immune cells drive aging throughout the body

This review explains how the immune system becomes dysfunctional with age, leading to chronic inflammation and organ damage that accelerates aging across the entire body.

This review explains how the immune system becomes dysfunctional with age, leading to chronic inflammation and organ damage that accelerates aging across the entire body. The authors argue that restoring immune function could be a …

Nature reviews. Immunology Feb 15, 2026

45 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

Life Expectancy Gains Are Slowing—Here's Why

A PNAS study shows that life expectancy improvements in high-income countries have decelerated 37-52% for cohorts born 1939-2000, primarily because infant mortality is now near zero, eliminating the easy statistical gains of the 20th century. …

r/longevity Feb 15, 2026

34 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How Hedgehog Signaling Might Combat Aging Across Multiple Organs

This review synthesizes evidence that activating Hedgehog signaling—a developmental pathway—may counteract hallmarks of aging like stem cell exhaustion and chronic inflammation across brain, liver, heart, and other tissues. While preclinical results are promising, the authors …

Experimental & molecular medicine Feb 13, 2026

35 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

How vaccines strengthen immunity and promote healthy aging

This review argues that strategic vaccination in older adults can combat age-related immune decline (immunosenescence) and reduce serious infections, hospitalizations, and death. The authors propose 'immunofitness' as a practical goal of healthy aging, supported by …

Human vaccines & immunotherapeutics Feb 12, 2026

30 Early