Machine Learning — OutliveHub

Preliminary Biomarkers — Aging clocks and measurement tools Observational PubMed

Can a Heart Ultrasound Tell Your True Age?

A simple heart ultrasound with AI software might reveal how much your cardiovascular system has aged, helping catch metabolic problems early.

Researchers used AI to estimate cardiovascular 'biological age' from simple heart ultrasounds in 243 adults. People whose heart appeared older than their calendar age had worse metabolic health markers and were twice as likely to …

European heart journal. Digital health

44 Early

Promising Biomarkers — Aging clocks and measurement tools Observational PubMed

How pregnancy ages some body systems while rejuvenating others—insights for slowing aging

Researchers analyzed 70 lab tests from 300,000 pregnancies and found that pregnancy triggers rapid aging in some systems (coagulation, thyroid, muscle) while rejuvenating others (kidney, iron, liver)—opposite to normal aging patterns. These 'rejuvenation' mechanisms could …

Nature communications

58 Promising

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other medRxiv

Disentangling physiological heterogeneity in retinal aging using a deep learning-based biological age framework

Biological age estimators quantify aging-related variation but provide limited insight into organ-specific aging processes. The retina enables non-invasive visualization of microvascular and neural structures and has emerged as a promising modality for biological age prediction. …

medrxiv (preprint)

34 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other medRxiv

A comprehensive map of how skeletal muscle ages at the genetic level

Researchers created an unprecedented atlas of gene activity in 1,675 human muscle biopsies, identifying over 3,000 genes that change with age and discovering that genes linked to muscle wasting in elderly people look strikingly similar …

medrxiv (preprint)

41 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other medRxiv

Testing a Personalized Digital Health Protocol to Boost Resilience in One Individual

Researchers conducted an intensive year-long self-study (N=1) combining time-restricted eating, exercise, Mediterranean diet, and continuous biomarker monitoring to assess how well a healthy person's body adapts to stress. The study demonstrates new methods for tracking …

medrxiv (preprint)

25 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins In Vitro PubMed

How a NAD+ mimic activates the aging-linked SIR2 protein through internal communication networks

Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …

PLoS computational biology

41 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Animal Model bioRxiv

Two-phase aging model reveals critical vulnerability period in flies and mice

Researchers identified a quantitative framework showing that aging proceeds in two distinct phases: a stable period followed by a transition to frailty marked by intestinal breakdown. They found that newly frail individuals face extreme early …

biorxiv (preprint)

33 Early

Promising Biomarkers — Aging clocks and measurement tools Observational PubMed

Your retinal images may reveal hidden aging and heart-kidney-metabolic disease risk

Researchers developed an AI model that estimates biological age from retinal photographs and found it correlates strongly with cardiovascular, kidney, and metabolic disease markers in over 30,000 people. This suggests eye imaging could become a …

Scientific reports

58 Promising

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other medRxiv

Development of a Multi-Trait Polygenic Score for Intrinsic Capacity

Background: Intrinsic capacity (IC) is a key marker of healthy ageing, which captures an individuals physical and mental capacities, measured across five domains: cognitive, locomotor, psychological, vitality, and sensory. Although genetic factors are known to …

medrxiv (preprint)

34 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

Bioactive peptide matrikines: discovery approaches for skin rejuvenation.

Ageing of human skin is driven in part by cumulative damage to extracellular matrix (ECM) proteins, resulting in wrinkles, laxity, and reduced capacity to heal. Bioactive peptide matrikines are promising therapeutic agents capable of stimulating …

American journal of physiology. Cell physiology

46 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other medRxiv

Aging Out of the Blue: Estimating and Calibrating Region-specific Epigenetic Clocks for a Blue Zone via SuperLearner

Epigenetic clocks estimate biological age from DNA methylation patterns at CpG sites, providing robust predictions of mortality and morbidity risk. "Blue zones"--regions of exceptional longevity--offer a unique opportunity to investigate how biological aging diverges from …

medrxiv (preprint)

34 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other bioRxiv

A single-cell atlas and aging clock define biological age and risk-associated stem cell states in human hematopoiesis

Aging of hematopoietic stem and progenitor cells (HSPCs) impairs regenerative capacity and predisposes to hematological diseases. Here, we constructed a comprehensive single-cell transcriptomic atlas comprising 186,123 CD34+ HSPCs spanning early prenatal development (6 post-conception weeks) …

biorxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools In Vitro PubMed

Growing human aging in a chip: A new lab model to test longevity drugs

Researchers created a miniature laboratory system using human stem cells that reproduces aging hallmarks in just 4 days—a process that normally takes decades. This 'aging-on-a-chip' could accelerate testing of anti-aging therapies and reveal how rejuvenation …

Nature biomedical engineering

45 Early

Preliminary Biomarkers — Aging clocks and measurement tools Cohort Study medRxiv

A blood test for cellular aging predicts disease and mortality risk

Researchers created an AI-powered blood biomarker (SASP Score) that measures senescent cell burden and successfully predicted mortality, dementia, heart attacks, and stroke in large population studies. The score also changed in response to exercise intervention, …

medrxiv (preprint)

40 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary Reddit

High-Dose Creatine for Brain Function: 2024 Study Breakdown and Dosing Insights

A Reddit user summarizes recent research suggesting single high-dose creatine (~20g) may improve cognitive processing by 24.

A Reddit user summarizes recent research suggesting single high-dose creatine (~20g) may improve cognitive processing by 24.5% during sleep deprivation, with vegetarians showing 2x greater benefits than meat-eaters. The post argues current 5g/day recommendations are …

r/Nootropics Feb 15, 2026

37 Early

Disputed AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other bioRxiv

How Your Brain Uses Predictions to Shape What You See

This paper presents a computational model of how the brain uses predictions and prior knowledge to filter and interpret sensory information. While the model shows promise in explaining existing behavioral and brain imaging data, it's …

biorxiv (preprint) Feb 13, 2026

24 Weak

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

Single-Cell Aging Clocks: Measuring Age at the Cellular Level

This review examines new tools called single-cell aging clocks that measure biological age in individual cells rather than averaging across thousands of cells at once. These tools reveal that aging varies dramatically between cell types …

Ageing research reviews Feb 12, 2026

36 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins In Vitro PubMed

New anti-cancer compounds show promise in mouse models of liver cancer

Researchers synthesized a new class of hybrid molecules combining an anti-cancer drug scaffold (sulfadiazine) with a 5-oximidazoline ring structure, and found that one compound (7l) killed liver cancer cells in the lab and extended survival …

Future medicinal chemistry Feb 12, 2026

36 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins In Vitro bioRxiv

How Hydra's body plan forms through molecular competition: new mathematical insights

Researchers created a mathematical model showing how two inhibitor proteins (Dickkopf) and Wnt signalling interact to form Hydra's body axis through mutual inhibition rather than the classical activator-inhibitor mechanism. This provides a mechanistic blueprint for …

biorxiv (preprint) Feb 12, 2026

28 Early

Promising AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Meta-Analysis bioRxiv

Brain networks underlying impulsive financial choices may help diagnose mental health conditions

This meta-analysis of 80 brain imaging studies identifies which research methods reliably detect the neural circuits involved in delay discounting—the tendency to prefer immediate rewards over future ones. The findings suggest that future studies should …

biorxiv (preprint) Feb 12, 2026

53 Promising