Researchers discovered that metformin extends lifespan in yeast by triggering changes in how genes are packaged (chromatin regulation), which activates retrotransposons—jumping genes that normally increase with age. Surprisingly, metformin increases these genetic elements' activity while …
This is a protocol paper describing an upcoming clinical trial that will test whether three drugs (metformin, fisetin, and spermidine) can reduce senescent cells and reverse aging hallmarks in healthy adults over 70 within three …
Researchers tested seven compounds known to slow aging in hermaphrodite worms on male worms and found that all extended lifespan, but only sulforaphane and metformin improved reproductive function in older males. This suggests that living …
Preliminary data shows metformin may delay onset of age-related diseases by 15-20%.
Background: GLP1 receptor agonists (GLP1RAs) and SGLT2 inhibitors (SGLT2Is) have established cardiovascular benefits for patients with type 2 diabetes mellitus (T2DM), with similar class-level effectiveness found in previous studies. However, real-world comparative effectiveness assessments of …
Geroscience has the goal of extending lifespan through geroprotective interventions. These interventions are typically imparted on groups of individuals, with their efficacy judged by increases in the average age-at-death. A more equitable outcome, which looks …
Researchers analyzed blood proteins from Swiss centenarians and discovered 37 proteins associated with a 'younger' profile that may explain why some people live to 100 and stay healthy. By comparing centenarian patterns across two independent …