Pharmacological — OutliveHub

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Can metformin keep muscles and bones strong as we age?

Metformin might help middle-aged people stay strong and mobile longer, but we need human studies to be sure.

Researchers gave middle-aged mice metformin (a common diabetes drug) and found it slowed aging-related weakness, preserved muscle mass and strength, and maintained bone and joint health. The findings suggest metformin might be a cheap, widely-available …

Biogerontology

42 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

A Bile Acid Supplement in Mom's Diet May Extend Her Offspring's Lifespan in Fruit Flies

Researchers fed pregnant fruit flies a high-fat diet supplemented with tauroursodeoxycholic acid (TUDCA), a bile acid derivative, and found their offspring lived ~19% longer with better stress resistance and mitochondrial health. The lifespan benefit depended …

The Journal of nutrition

39 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Bisdemethoxycurcumin extends lifespan and healthspan in Caenorhabditis elegans via modulation of EGFR-linked signaling pathways.

Bisdemethoxycurcumin (BDMC) is a natural curcuminoid with higher solubility and stability than curcumin, yet its potential role in lifespan and healthspan regulation remains largely unexplored. This study aimed to investigate the effects of BDMC on …

Food & function

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Repositioning Non-Ablative Fractional Lasers - Molecular and Histological Insights from a scoping review.

Near-infrared non-ablative fractional lasers (NAFL) are established for skin rejuvenation and scar treatment and have attracted interest for their expanding therapeutic potential. This scoping review aims to revisit and reposition NAFL within a fluence-dependent continuum …

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Melanocyte proliferation gene 1 regulated metabolic reprogramming in acute myocardial infarction based on the AMPK/mTOR pathway.

Melanocyte proliferation gene 1 (MYG1) has been implicated in cellular metabolic regulation; however, its role in cardiomyocyte metabolic reprogramming during acute myocardial infarction (AMI) remains unclear. In this study, a rat AMI model was established, …

Toxicology and applied pharmacology

38 Early

Promising Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Exercise's Brain-Boosting Molecule Reverses Memory Loss by Cleaning Up Blood Vessels

Researchers identified a liver-derived protein called GPLD1 that transfers exercise's cognitive benefits to the brain by targeting blood vessel dysfunction. In aging and Alzheimer's mouse models, boosting GPLD1 or blocking its downstream target TNAP restored …

Cell

59 Promising

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

A plant compound slowed aging in worms and mice by tweaking metabolism

A plant extract slowed aging and brain decline in mice—but we don't yet know if it works in humans.

Researchers isolated a fructan sugar compound (PKP-1b) from a traditional Chinese medicinal plant and found it extended lifespan and reduced aging signs in C. elegans and mice by dampening insulin/IGF-1 signaling—a well-known aging pathway. While …

Carbohydrate polymers

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Mechanistic insights into aging and longevity: Implications for ovarian function and health.

Ovarian aging is characterized by progressive follicular reserve depletion, mitochondrial dysfunction, oxidative stress, and endocrine decline. This review examines the molecular mechanisms driving ovarian aging and evaluates emerging therapeutic strategies to preserve reproductive longevity. Key …

Tissue & cell

46 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

CPT2 as a Convergent Node Linking Age-Associated Neuronal H3K27me3 Remodeling to Nicotinamide Mononucleotide (NMN)-Induced Expression Rescue in Metabolic Tissues.

Age-related decline in mitochondrial function and disruption of epigenetic regulation are two closely connected features of biological aging. In neurons, age-associated remodeling of repressive H3K27me3 chromatin may constrain genes needed for metabolic, synaptic, and stress-adaptive …

Cureus

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Curcumin Attenuates Cuproptosis via Activating Autophagy Through Inhibition of the AKT/mTOR/P70S6K-Signaling Pathway in Parkinson's Disease Models.

This research surveyed the therapeutic potential of curcumin (Cur) in Parkinson's disease (PD), focusing on its effects on cuproptosis and underlying molecular mechanisms. A MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced mouse model and a MPP+ (1-methyl-4-phenylpyridinium)-treated PC12 cell model …

Molecular neurobiology

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Can metformin protect aging hearts from stress? Early evidence in mice

A cheap, common diabetes drug might help keep hearts young by protecting them from stress damage during middle age.

Researchers gave middle-aged mice metformin and then exposed them to heart stress. Metformin-treated mice showed better cardiac function and healthier mitochondria (the cell's energy factories) compared to untreated mice. This suggests metformin might help hearts …

Experimental gerontology

40 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary PubMed

How a cellular energy molecule could slow kidney damage from diabetes

This research maps a potential drug target to slow kidney damage in diabetes, but human proof is still missing.

This review examines how NAD+ and a protein called SIRT3 control mitochondrial health in diabetic kidney disease, showing promising preclinical results but noting a critical gap: almost no human clinical evidence yet. If confirmed in …

Renal failure

36 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Synergistic dual targeting of mTOR and GLS1 overcomes glutamine-driven resistance in triple-negative breast cancer.

Resistance to therapeutic agents represents a critical barrier in the clinical management of triple-negative breast cancer (TNBC), necessitating novel therapeutic strategies. We discovered that mammalian target of rapamycin (mTOR) and glutaminase 1 (GLS1) mediated glutamine …

Pharmacological research

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Ligustilide Attenuates Neuroinflammation and Fibrosis in an Aluminum Chloride-induced Rat Model of Alzheimer's Disease via mTOR/STAT3 Signaling Inhibition.

Alzheimer's disease (AD) affects approximately 50 million individuals worldwide and is projected to triple by 2050. Ligustilide is a naturally occurring compound with varied pharmacological actions. Ligustilide has been reported to ameliorate AD by inhibiting …

The Keio journal of medicine

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other bioRxiv

Mitochondrial structural and functional defects in the Drosophila melanogaster model of PLA2G6 Associated Neurodegeneration (PLAN)

PLA2G6-associated neurodegeneration (PLAN) is a rare progressive disorder caused by mutations in PLA2G6, which encodes calcium-independent phospholipase A2, an enzyme required for phospholipid remodeling and membrane lipid homeostasis through the Lands cycle. Although mitochondrial dysfunction …

biorxiv (preprint)

39 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other bioRxiv

Senescent cells are more susceptible to reductive stress-induced cell death: implications for senolytic research.

Proliferating cells can enter an irreversible state of cell-cycle arrest known as cellular senescence. The accumulation of senescent cells contributes to organismal ageing and age-related pathologies. Consequently, therapeutic strategies have emerged to selectively eliminate senescent …

biorxiv (preprint)

34 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Rejuvenating Inter-organellar Communication Via Mitophagy in Ageing and Neurodegeneration.

Ageing and neurodegeneration are characterized by the progressive breakdown of organellar communication between mitochondria, the endoplasmic reticulum (ER), and lysosomes. Recent findings underline mitophagy as a central modulator of this interconnected network. Impaired mitophagy induces …

Current neuropharmacology

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Dual binding modes of Quercetin to BSA: Insights from spectroscopy and molecular simulations in amyloid suppression.

The rising incidence of neurodegenerative disorders linked to protein fibrillation in aging populations highlights the need for efficient, low-toxicity fibrillation inhibitors. Quercetin, a natural flavonoid, shows potential in both suppressing fibrillation and disaggregating mature fibrils. …

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Intermittent Fasting Attenuates Cognitive Decline in D-Galactose-Induced Aging Rats in Association with β-Hydroxybutyrate and PI3K/AKT/GSK-3β Signaling.

Age-related cognitive decline is a major public health concern, with few effective interventions available. Intermittent fasting (IF) has emerged as a promising metabolic intervention, potentially enhancing neuroprotection through increased β-hydroxybutyrate (BHB) production. This study aimed …

Neurochemical research

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Site-specific trastuzumab Fab-DM1 via butelase-1 with ABD fusion for potent HER2-positive tumor control.

Antibody-drug conjugates (ADCs) are constrained by limited tumor penetration of IgG formats and heterogeneity from stochastic conjugation. We addressed these challenges by engineering a compact trastuzumab Fab-based ADC with site-specific installation of DM1 using the …

Medical oncology (Northwood, London, England)

38 Early