Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ boosters, and the molecules in clinical trials right now.
Bisdemethoxycurcumin (BDMC) is a natural curcuminoid with higher solubility and stability than curcumin, yet its potential role in lifespan and healthspan regulation remains largely unexplored. This study aimed to investigate the effects of BDMC on …
Stress granules (SGs), membrane-less organelles formed via liquid-liquid phase separation (LLPS), function as essential adaptive compartments that sequester mRNAs and proteins during acute stress. However, during chronic stress or aging, these dynamic condensates can undergo …
Near-infrared non-ablative fractional lasers (NAFL) are established for skin rejuvenation and scar treatment and have attracted interest for their expanding therapeutic potential. This scoping review aims to revisit and reposition NAFL within a fluence-dependent continuum …
Researchers identified a liver-derived protein called GPLD1 that transfers exercise's cognitive benefits to the brain by targeting blood vessel dysfunction. In aging and Alzheimer's mouse models, boosting GPLD1 or blocking its downstream target TNAP restored …
Resistance to therapeutic agents represents a critical barrier in the clinical management of triple-negative breast cancer (TNBC), necessitating novel therapeutic strategies. We discovered that mammalian target of rapamycin (mTOR) and glutaminase 1 (GLS1) mediated glutamine …
Alzheimer's disease (AD) affects approximately 50 million individuals worldwide and is projected to triple by 2050. Ligustilide is a naturally occurring compound with varied pharmacological actions. Ligustilide has been reported to ameliorate AD by inhibiting …
PLA2G6-associated neurodegeneration (PLAN) is a rare progressive disorder caused by mutations in PLA2G6, which encodes calcium-independent phospholipase A2, an enzyme required for phospholipid remodeling and membrane lipid homeostasis through the Lands cycle. Although mitochondrial dysfunction …
The rising incidence of neurodegenerative disorders linked to protein fibrillation in aging populations highlights the need for efficient, low-toxicity fibrillation inhibitors. Quercetin, a natural flavonoid, shows potential in both suppressing fibrillation and disaggregating mature fibrils. …
As tumors expand and encounter hypoxia and nutrient deprivation, cancer cells must establish tight coordination between metabolic reprogramming, protein synthesis and secretory activity to enable effective adaptation. The mechanistic target of rapamycin (mTOR) pathway plays …
Goals in plastic surgery and aesthetic medicine include minimizing healing complications, optimize aesthetic outcomes and improve patient satisfaction. Platelet-derived growth factor BB (PDGF-BB) is among the most potent natural activators of healing. A pharmaceutical copy …
The global emergence of multidrug-resistant (MDR) and hypervirulent (hvKp) Klebsiella pneumoniae strains poses a major clinical challenge. Here, we compared representative classical (cKp), MDR-Kp, and hvKp isolates to define host epigenetic responses during infection. At …
Inflammation in the pancreas drives acinar-to-ductal metaplasia (ADM), a progenitor-like state that can be hijacked by mutant Kras in the formation of pancreatic ductal adenocarcinoma. How these cell fate decisions vary according to KRAS mutation …
Atg8ylation is an autophagy associated response to membrane damage that recruits mammalian ATG8 proteins (mATG8s) to damaged membranes to promote their repair or removal. Here, we show that the SARS-CoV-2 protein ORF3a induces lysosomal membrane …
Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) are overexpressed in breast cancer and drive oncogenesis, rendering PI3K/mTOR inhibitors as promising therapeutic agents. However, tumor cells readily develop resistance to single-agent PI3K or mTOR …
Autophagy is a catabolic process that degrades cytoplasmic materials and is controlled by nutrient availability and signaling. The plasma membrane-associated pyruvate-solute carrier hermes (hrm) is required for regulation of the mechanistic target of rapamycin (mTOR) …
Researchers found that 3,5-dicaffeoylquinic acid (3,5-diCQA), a compound from plants, delayed aging and improved stress resistance in worms and human cells by activating a well-known cellular defense pathway called SKN-1/Nrf2. The compound appears to work …
Mesenchymal stem cells have emerged as a pivotal focus in regenerative medicine and therapeutic innovation due to their multipotent differentiation capacity and immunomodulatory properties. A major obstacle in maintaining human MSC potency and subsequently, the …
Researchers found that terbinafine (an antifungal) and miglustat (a diabetes drug) activate mitochondrial stress responses that extended lifespan and improved health markers in C. elegans worms and human cells. The discovery suggests these existing drugs …
The traditional Chinese medicinal plant Conyza blinii contains a wealth of bioactive compounds derived from its endophytic fungi, which hold considerable potential for antioxidant applications and cancer prevention and treatment. Nevertheless, in vivo pharmacological studies …
Researchers fed pregnant fruit flies a high-fat diet supplemented with tauroursodeoxycholic acid (TUDCA), a bile acid derivative, and found their offspring lived ~19% longer with better stress resistance and mitochondrial health. The lifespan benefit depended …