NAD+ precursors including NMN and nicotinamide riboside
Researchers analyzed blood chemistry in 213 people over 100 years old and found they have distinctly different metabolic profiles—especially higher bile acids and lower inflammatory markers—compared to younger controls. By identifying these metabolic signatures, they …
Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …
Rhododendron pachypodum flowers are traditionally consumed by ethnic minorities in Yunnan as seasonal edible flowers, yet their bioactive iridoid constituents and associated biological activities remain underexplored. This study characterized the iridoid constituents and evaluated in …
Different types of dietary restriction (DR) have been practiced by humans for religious and medical purposes for millennia, but only during the past three decades has the scientific study of DR at cellular and molecular …
Pseudomonas aeruginosa is a priority pathogen in chronic and multidrug-resistant infections, yet therapeutic phages targeting this organism often exhibit variable and unpredictable efficacy. A mechanistic understanding of the genomic determinants governing phage-host interactions is therefore …
Disruption of the circadian clock as well as reduced NAD+ levels are both hallmarks of aging. While circadian rhythms and NAD+ metabolism have been linked in heart disease, their relationship during cardiac aging is less …
Researchers used lab-grown cells to show that mitochondrial DNA variants affecting energy production influence telomere length by controlling reactive oxygen species and NAD levels. This suggests that inherited mitochondrial traits may influence how quickly our …
This review examines NAD+—a crucial molecule for cellular energy and stress response—as a potential therapeutic target for age-related ovarian decline and disorders like polycystic ovary syndrome. The authors conclude that while NAD+ deficiency appears central …
Researchers found that 3,5-dicaffeoylquinic acid (3,5-diCQA), a compound from plants, delayed aging and improved stress resistance in worms and human cells by activating a well-known cellular defense pathway called SKN-1/Nrf2. The compound appears to work …
Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores. However, the study is very small, lacks …
Dr. Brad Stanfield critically examines the NAD-boosting supplement trend, tracing it from compelling animal studies to disappointing human clinical trials and failed reproducibility attempts. He argues that despite initial excitement around NMN and NR supplements, …
Beta-hydroxybutyrate (BHB), a ketone body produced during ketogenic diets and caloric restriction, correlates with lifespan extension in mice and appears mechanistically linked to longevity through glucagon signaling. The video presents mouse model data showing BHB's …
Dr. Charles Brenner, a leading NAD researcher and discoverer of nicotinamide riboside, discusses why NAD levels matter for aging, exercise recovery, and disease prevention. He clarifies common misconceptions about NAD decline with age and explains …
A Reddit user summarizes recent research suggesting single high-dose creatine (~20g) may improve cognitive processing by 24.5% during sleep deprivation, with vegetarians showing 2x greater benefits than meat-eaters. The post argues current 5g/day recommendations are …
Researchers discovered that while different causes of muscle wasting (cancer, steroid use, and aging) trigger mostly distinct molecular changes, they all share one common signature: reduced chemical modification of a protein called Lrpprc. Restoring this …