NAD+ precursors including NMN and nicotinamide riboside
BACKGROUND: Reproductive aging represents a critical physiological bottleneck characterized by a progressive decline in tissue homeostasis and physiological function. While the gut microbiota is known to shift during host aging, the ecological forces governing the …
Researchers isolated a fructan sugar compound (PKP-1b) from a traditional Chinese medicinal plant and found it extended lifespan and reduced aging signs in C. elegans and mice by dampening insulin/IGF-1 signaling—a well-known aging pathway. While …
This review examines how NAD+ and a protein called SIRT3 control mitochondrial health in diabetic kidney disease, showing promising preclinical results but noting a critical gap: almost no human clinical evidence yet. If confirmed in …
This review examines SIRT1, a protein activated by exercise that helps counteract multiple aging processes across the body. Evidence from animal and human studies shows different exercise types can boost SIRT1 levels in key organs, …
Researchers tested a specially formulated NAD+ supplement (LNAD+) in a small randomized trial and found it rapidly increased NAD+ inside cells by 53% compared to placebo, while leaving blood NAD+ unchanged. The treatment was well-tolerated …
Researchers tested injectable forms of nicotinamide riboside (NR), a compound that boosts NAD+ levels, in two small Phase 1 trials with 84 total participants. The injections were well-tolerated with no serious safety concerns, though some …
Researchers found that vitamin K2 extended lifespan in C. elegans worms by reducing cellular stress and protecting mitochondria—the powerhouses of cells. The effect worked through a specific molecular pathway known to regulate aging. However, this …
This review examines NAD+—a crucial molecule for cellular energy and stress response—as a potential therapeutic target for age-related ovarian decline and disorders like polycystic ovary syndrome. The authors conclude that while NAD+ deficiency appears central …
Researchers found that 3,5-dicaffeoylquinic acid (3,5-diCQA), a compound from plants, delayed aging and improved stress resistance in worms and human cells by activating a well-known cellular defense pathway called SKN-1/Nrf2. The compound appears to work …
Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …
Rhododendron pachypodum flowers are traditionally consumed by ethnic minorities in Yunnan as seasonal edible flowers, yet their bioactive iridoid constituents and associated biological activities remain underexplored. This study characterized the iridoid constituents and evaluated in …
Different types of dietary restriction (DR) have been practiced by humans for religious and medical purposes for millennia, but only during the past three decades has the scientific study of DR at cellular and molecular …
Pseudomonas aeruginosa is a priority pathogen in chronic and multidrug-resistant infections, yet therapeutic phages targeting this organism often exhibit variable and unpredictable efficacy. A mechanistic understanding of the genomic determinants governing phage-host interactions is therefore …
Disruption of the circadian clock as well as reduced NAD+ levels are both hallmarks of aging. While circadian rhythms and NAD+ metabolism have been linked in heart disease, their relationship during cardiac aging is less …
Researchers used lab-grown cells to show that mitochondrial DNA variants affecting energy production influence telomere length by controlling reactive oxygen species and NAD levels. This suggests that inherited mitochondrial traits may influence how quickly our …
Researchers analyzed blood chemistry in 213 people over 100 years old and found they have distinctly different metabolic profiles—especially higher bile acids and lower inflammatory markers—compared to younger controls. By identifying these metabolic signatures, they …
This review argues that combining topical skin treatments (retinoids, peptides, antioxidants) with internal supplements (NAD+ precursors, collagen peptides, polyphenols) can target multiple aging mechanisms simultaneously. While conceptually sound, the paper is a narrative review without …
Researchers genetically modified fruit flies to increase a molecule called NAD+ specifically in their mitochondria (cellular power plants), and found this extended their lifespan and reversed Alzheimer's-like symptoms. This suggests that the NAD+/NADH balance is …
Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores. However, the study is very small, lacks …
Dr. Brad Stanfield critically examines the NAD-boosting supplement trend, tracing it from compelling animal studies to disappointing human clinical trials and failed reproducibility attempts. He argues that despite initial excitement around NMN and NR supplements, …