Protein Folding

AlphaFold and protein structure prediction in aging research

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins In Vitro PubMed

How a NAD+ mimic activates the aging-linked SIR2 protein through internal communication networks

Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …

PLoS computational biology
41 Early
Design 5
Sample 8
Peer Review 13
Replication 5
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms In Vitro bioRxiv

How insulin receptors move in muscle cells: new insights into a diabetes mechanism

Researchers used advanced imaging and mass spectrometry to map how insulin receptors behave in muscle cells, discovering they travel via two different cellular pathways—one involving caveolin and one involving clathrin. This fundamental understanding of insulin …

biorxiv (preprint) Feb 12, 2026
28 Early
Design 5
Sample 6
Peer Review 3
Replication 5
Transparency 9
How we score →