AlphaFold and protein structure prediction in aging research
Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …
Researchers discovered that naked mole rats—which live 10x longer than similar-sized rodents—have undergone massive evolutionary changes in protein structure, particularly in regions that handle stress and prevent cancer. These changes appear to stabilize certain proteins …
The CRISPR/Cas9 method facilitates targeted disruption of gene sequences, providing a reliable means to analyze gene-dependent regulatory pathways. This study aims to investigate melanogenesis in p21-knockout B16F1 cells generated by the CRISPR/Cas9 system. The mutation …
Researchers used advanced imaging and mass spectrometry to map how insulin receptors behave in muscle cells, discovering they travel via two different cellular pathways—one involving caveolin and one involving clathrin. This fundamental understanding of insulin …