Researchers used C. elegans to show that the mTOR protein, when active specifically inside neurons, promotes certain aging changes in nerve cells—particularly the growth of unwanted branches—without affecting overall lifespan. This finding narrows down where …
Acute-on-chronic liver failure (ACLF) is a severe liver syndrome marked by systemic inflammation and high mortality, often complicated by autophagy impairment and mitochondrial dysfunction. This study investigates atractylenolide I (AT-1), a compound from Atractylodes macrocephala, …
Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), has shown promise as a neuroprotective compound in preclinical studies. Reduced brain glucose metabolism and loss of synaptic density are key features of Alzheimer's disease …
BackgroundGeroprotective interventions, including the mTOR inhibitor rapamycin, slow aging in preclinical models. Translation to humans remains challenging because clinical trials require endpoints detectable within feasible timeframes. Multi-modal in vivo imaging could address this limitation by …
Ovarian aging is characterized by progressive follicular reserve depletion, mitochondrial dysfunction, oxidative stress, and endocrine decline. This review examines the molecular mechanisms driving ovarian aging and evaluates emerging therapeutic strategies to preserve reproductive longevity. Key …
Melanocyte proliferation gene 1 (MYG1) has been implicated in cellular metabolic regulation; however, its role in cardiomyocyte metabolic reprogramming during acute myocardial infarction (AMI) remains unclear. In this study, a rat AMI model was established, …
Researchers gave aging mice rapamycin and found it prevented the normal decline in movement and motor control, with females benefiting more than males. The benefits appear linked to reduced oxidative stress and cellular stress in …
Researchers created an unprecedented atlas of gene activity in 1,675 human muscle biopsies, identifying over 3,000 genes that change with age and discovering that genes linked to muscle wasting in elderly people look strikingly similar …
Maternal inflammatory response (MIR) during early gestation in mice induces a cascade of physiological and behavioral changes that have been associated with autism spectrum disorder (ASD). In a prior study and the current one, we …
Geroscience has the goal of extending lifespan through geroprotective interventions. These interventions are typically imparted on groups of individuals, with their efficacy judged by increases in the average age-at-death. A more equitable outcome, which looks …
BACKGROUND: Immunothrombosis entails a tight interplay between thrombotic and inflammatory pathways and plays a pathological role in ischemic stroke and venous thrombosis. The mTOR (mechanistic target of rapamycin) is a canonical serine/threonine kinase and is …
In this study, the effect of dietary taurine (Tau) on the innate immune responses, digestive function, and mammalian target of rapamycin (RAPA; mTOR) signaling was investigated in coho salmon (Oncorhynchus kisutch). Coho salmon were fed …
Focal cortical dysplasia type II (FCDII), a major cause of pediatric drug-resistant focal epilepsy, results from brain somatic variants in mTOR pathway genes, including germline and somatic second-hit loss-of-function variants in the mTOR repressor DEPDC5. …
Heterozygous mutations in the Glucocerebrosidase gene (GBA1), encoding the lysosomal hydrolase Beta-glucocerebrosidase (GCase), are a genetic risk factor for Parkinsons disease (PD). To explore the pathophysiological consequences of these mutations, we have used fibroblasts and …
Biallelic pathogenic variants in STRADA (STE20-related adaptor alpha), an upstream regulator of the mechanistic target of rapamycin (mTOR) pathway, result in megalencephaly, drug-resistant epilepsy, and severe intellectual disability. This study explores how mTOR pathway hyperactivity …
Reactive oxygen species (ROS) are essential second-messenger molecules, yet when deregulated, they fuel cancer growth and therapeutic resistance. In high-grade gliomas, including glioblastoma, diffuse hemispheric glioma, and diffuse midline glioma (DMG), genetic, epigenetic, and metabolic …
Despite advances in diabetes management, diabetic kidney disease (DKD) remains a leading cause of end-stage renal disease. We investigated whether mesenchymal stem cells (MSCs) and their conditioned medium, containing the MSC-derived secretome, protect against DKD …
Dysregulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of the rapamycin (PI3K/Akt/mTOR) pathway and its complex interplay with autophagy is a crucial mechanism driving proliferation, survival, and therapeutic resistance in cancer. Natural products offer a …
Polysaccharides from edible mushrooms are promising dietary ingredients for functional foods due to their potent antioxidant and cytoprotective activities. Given the scarcity of safe and effective dietary strategies against X-ray-induced male reproductive system damage, this …
Hepatic ischemia-reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy. We evaluated Leonurine (SCM-198) as a hepatoprotective agent. Male C57BL/6 mice were pretreated with SCM-198 for 7 days, then subjected to hepatic …