Polyphenol found in red wine with sirtuin-activating properties
Resveratrol is an antioxidant polyphenolic compound found in grape skins and red wine. It has been suggested that resveratrol mediates sirtuin 1 (SIRT1) activation, leading to anti-aging, life extension, and anti-cancer effects as demonstrated primarily …
Conventional food packaging functions as a passive barrier, failing to dynamically counter microbial contamination that accounts for 30-40% of postharvest losses. Herein, inspired by polyphenol coordination chemistry, a light-driven, metal-phenolic coordination system was engineered with …
BACKGROUND: Chronic low-grade inflammation ("inflammaging") is a key driver of age-related pathologies including cardiovascular disease, neurodegeneration, and metabolic syndrome. Diet plays a dual role in modulating this process, acting both as a source of pro-inflammatory …
Aging, a complex process influenced by genetic and environmental factors, is a major determinant of health and disease. The polyphenolic compound resveratrol, known for its antioxidant properties, has been widely studied for its potential anti-aging …
Cotinus coggygria Scop. is a polyphenol-rich medicinal plant traditionally used in topical preparations, and the formulation-dependent effects of its extracts on fibroblast behavior remain insufficiently characterized. In this study, a 60% ethanol extract of C. …
Researchers tested seven compounds known to slow aging in hermaphrodite worms on male worms and found that all extended lifespan, but only sulforaphane and metformin improved reproductive function in older males. This suggests that living …
Researchers found that 3,5-dicaffeoylquinic acid (3,5-diCQA), a compound from plants, delayed aging and improved stress resistance in worms and human cells by activating a well-known cellular defense pathway called SKN-1/Nrf2. The compound appears to work …
Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …
BACKGROUND: Cancer is a significant global health challenge, affecting millions of people every year. Overall survival rates have improved over time, but some patients exhibit treatment resistance, prompting ongoing research to find suitable and effective …
Mesenchymal stem cell (MSC)-derived exosomes are emerging as cell-free bioregenerative platforms in aesthetic dermatology. Umbilical cord (UC-MSC) and adipose-derived (AD-MSC) exosomes are among the most studied sources, yet existing data derive from heterogeneous models that …
Ovarian aging is characterized by progressive follicular reserve depletion, mitochondrial dysfunction, oxidative stress, and endocrine decline. This review examines the molecular mechanisms driving ovarian aging and evaluates emerging therapeutic strategies to preserve reproductive longevity. Key …
This review argues that combining topical skin treatments (retinoids, peptides, antioxidants) with internal supplements (NAD+ precursors, collagen peptides, polyphenols) can target multiple aging mechanisms simultaneously. While conceptually sound, the paper is a narrative review without …
Parkinson's disease (PD), a progressive neuropathy marked by abnormal α-synuclein (α-Syn) deposition and oxidative stress-driven degeneration of dopaminergic neurons (DA neurons), remains inadequately addressed by current palliative strategies that primarily provide symptomatic relief, emphasizing the …
Polyphenols are compounds synthesized by plants as part of their chemical defense system to counteract biotic and abiotic stressors. These compounds share two key chemical characteristics: their aromatic groups make them insoluble in water, while …
The quest for an elixir of longevity has long inspired research into molecular mechanisms that govern aging. The present study investigated the effects of resveratrol (RV) and nanodiamonds (NDs) on sirtuin activity, oxidative stress, and …
This study presents the fabrication of arrowroot starch (ARS)-based bionanocomposite films, plasticized with glycerol, reinforced with nanocellulose (NC), and enriched with cumin seed oil (CSO), aimed at sustainable, smart food packaging applications. The optimized formulation …
Glucose oxidase (GOX) is widely recognized for its potential in food preservation, yet its practical application is often limited by insufficient stability and catalytic efficiency under processing conditions. In this study, a GOX from Aspergillus …
Age-related deterioration of the intestinal epithelial barrier exacerbates systemic metabolic and functional decline, highlighting the gut as a key target for dietary interventions in healthy aging. Here, using naturally aged mice and intestinal organoids, we …
Polyphenols are a class of plant-derived phytochemicals with potent antioxidant and anti-aging activities. However, current research has largely focused on free polyphenols, whereas dietary fiber-associated bound polyphenols remain insufficiently explored. In this study, bound polyphenols …
The goal of developing interventions to slow ageing is not only lifespan extension but more importantly to increase healthspan, the period of life spent in active good health. Nutritional interventions have emerged as a potential …