Spermidine emerges as top longevity nutrient in 15-year study of 146 compounds

A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5.

A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5.7 years of age reduction. The post acknowledges important uncertainty: spermidine may simply be a …

53 Promising
Design 9
Sample 10
Peer Review 12
Replication 9
Transparency 13

How polyamines control aging: New insights into a cellular anti-aging mechanism

This review synthesizes evidence that polyamines—small molecules that naturally decline with age—regulate multiple aging pathways including oxidative stress, gene expression, and protein synthesis. While animal studies show spermidine supplementation extends lifespan, human evidence remains limited, …

36 Early
Design 4
Sample 2
Peer Review 11
Replication 10
Transparency 9