How We Score
How we vet the research — transparency first
Making Epigenetic Age Clocks Work with DNA Sequencing Data
This preprint describes a useful technical solution for adapting aging clocks to work with modern DNA sequencing, but it's too early to rely on these findings. Wait for peer review …
Eye fluid reveals mitochondrial damage in vision loss; alpha-ketoglutarate supplement shows promise
This early-stage, unreviewed study shows an innovative way to measure mitochondrial health in living human eyes and provides preliminary evidence that alpha-ketoglutarate supplementation can reach the eye and shift its …
NAD Precursors: What Science Says About NR vs NMN Supplements
NAD+ is genuinely important for cellular health, but the claim that NR supplements are superior to NMN or provide major exercise benefits in healthy people goes beyond current evidence. Rely …
Mike Lustgarten's Self-Experiment: NAD+ and Homocysteine Supplementation
This is a well-documented personal experiment showing one person's biomarker changes from supplementation, characterized by admirable honesty about disappointing results—but it provides no evidence that this supplement protocol actually slows …
Genetics May Account for 50% of Lifespan, New Study Suggests
While the genetic contribution to lifespan is a legitimate research question, this post cites an unverifiable study without sufficient detail to evaluate its claims. Readers should be cautious about the …
How SARS-CoV-2 Shuts Down Host Cells' Protein-Making Machinery
This study reveals a clever trick SARS-CoV-2 uses to quiet host cells while amplifying its own protein production, targeting a pathway implicated in aging. However, it's a preliminary report in …
How Your Brain Uses Predictions to Shape What You See
This is a theoretical neuroscience paper with no direct bearing on aging or longevity. While the computational model is interesting for understanding how brains use predictions, the lack of peer …