How We Score
How we vet the research — transparency first
How CMV Drives Aging in HIV Patients—And What We Can Do About It
CMV is a hidden driver of accelerated aging in people with HIV, but it's druggable: early trials of antivirals and vaccines show promise, and larger studies could transform care. This …
Can senolytic drugs restore fertility in female mice with fatty liver disease?
A mouse study suggests senolytic drugs might improve fertility in females with fatty liver disease by reducing cellular aging in the ovaries, though they don't actually fix the liver disease. …
Can we reverse aging by partially reprogramming cells?
Partial reprogramming is a promising concept for reversing aging at the cellular level, with encouraging early results in animals. However, it remains largely unproven in humans—think of this as a …
Rapamycin reduces age-related motor decline in mice, especially in females
Rapamycin preserved movement and motor control in aging mice, particularly in females, seemingly by reducing cellular stress in the brain. This is encouraging but still preliminary—animal findings require human testing …
Reversing cell aging in stem cells using temporary genetic reprogramming
This is a promising proof-of-concept for temporarily 'resetting' aging in stem cells using non-integrating viral vectors, but it's early-stage laboratory work. Before this can help patients, researchers need to test …
Natural compound DMB reduces cellular aging by activating DNA repair protein FEN1
This is a solid proof-of-concept study showing a natural compound can reduce cellular aging markers in the lab and extend lifespan in worms—promising enough to justify further study, but too …
How chemical marks on RNA control telomeres and aging
This thoughtful review proposes that chemical tags on RNA—not just DNA mutations—are key regulators of telomere aging, and highlights promising research directions. However, it presents no new experimental proof; the …
How bats' virus defenses may hold secrets to extreme longevity
This early-stage work suggests that bats' extreme longevity may stem from evolved adaptations that let them tolerate viruses peacefully—and these same genes protect against cancer. It's an intriguing hypothesis that …