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Single-cell-scale spatial transcriptome reveals early regional priming of the developing mouse ovary

Phthalate Esters in Aquatic Ecosystems: A Multiscale Threat from Molecular Disruption to Ecological Risks.

TREM2+ macrophages accumulate in alveoli of human pulmonary tuberculosis providing a permissive niche for bacterial growth

Natural Antimicrobial Activity of Nettle (Urtica dioica L.) Leaf Extract for Shelf-Life Extension of Mashed Potatoes.

Nora virus proliferates in dividing intestinal stem cells and thereby sensitizes Drosophila flies to Pseudomonas aeruginosa intestinal infection and to oxidative stress

Urban Care Farming to Enhance Quality of Life Among Older Adults: Protocol for a Waitlist Randomized Trial.

Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity

Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology.

Aging and longevity in decades-old genebanked seeds from U.S. endangered plant species: Assessments using survival and RNA integrity assays.

A data-driven dietary pattern anchored to slower epigenetic aging is associated with a spectrum of aging-related health outcomes

Comparative Cardiovascular Effectiveness of Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors in Diabetes Mellitus

A Dialectical Behavior Therapy Skills Training Intervention for Cigarette Smoking by Patients with Cancer: Focused Qualitative Inquiry Prior to Feasibility Trial

Can We Restore Aging Immune Systems to Make Cancer Drugs Work Better?

This is a thoughtful overview of promising but unproven strategies to restore immune function in older cancer patients, not a definitive study showing they work. The real test will come …

A protein that clears harmful RNA buildup could be key to aging

A newly discovered enzyme prevents aging-related RNA damage in animals, suggesting a promising target for longevity therapies—but this finding is too recent to confirm and needs independent replication before clinical …

A New Blood Test that Predicts Aging and Disease Risk Across Millions of People

This is rigorous work that validates a promising new way to measure biological age using standard blood tests across a large, diverse population. However, it's too early to use this …

How Caloric Restriction Reshapes Your Metabolism Over 2 Years

This well-designed study provides the first detailed snapshot of metabolic changes during long-term caloric restriction in humans, showing that carbohydrate and fat metabolism shift in time-dependent ways. However, as an …

Your retinal images may reveal hidden aging and heart-kidney-metabolic disease risk

This is a well-executed observational study showing that an AI-analyzed eye photograph correlates with cardiovascular and metabolic disease risk, but it's not yet proof that this screening tool will help …

A Natural Plant Compound Slows Aging in Worms by Boosting Cellular Cleanup

Corylin shows genuine promise in a worm model by activating well-established longevity pathways, but these are early-stage findings. Don't expect human supplements or treatments from this work alone—much validation in …

Two-phase aging model reveals critical vulnerability period in flies and mice

This preprint offers an intriguing mathematical framework showing aging may involve a dangerous transition point—but it's early-stage work awaiting peer review and replication. If confirmed, it could refocus aging research …

Plant extract Salvia plebeia triggers cellular cleanup and reverses aging signs in mice

A plant extract activates cellular cleanup (autophagy) and reverses aging markers in mice, with a compound called rosmarinic acid identified as the likely active ingredient—an interesting lead, but human studies …