Research on cellular-level aging mechanisms
INTRODUCTION: Skin aging arises from intrinsic processes and extrinsic insults (e.g., ultraviolet exposure and oxidative stress). Mesenchymal stromal cell (MSC)-derived secretome offers a cell-free approach to skin regeneration. Wharton's jelly-derived MSCs (WJ-MSCs) may outperform adipose-derived …
Researchers tested whether dasatinib and quercetin—drugs that eliminate senescent (aging) cells—could prevent bone loss in the jaw. The treatment worked in naturally aged mice but failed in a gum disease model, suggesting senolytic benefits may …
Natural killer (NK) cells, a type of potent cytotoxic lymphocyte, are particularly promising for the treatment of cancers that lose or downregulate major histocompatibility complex class I (MHC class I) expression to evade T cell-mediated …
INTRODUCTION: Skin aging, marked by wrinkles, volume loss, and reduced hydration, has driven growing interest in minimally invasive aesthetic treatments to restore skin quality and appearance. This study aimed to evaluate the efficacy and safety …
Researchers discovered that aging planarians (regenerative flatworms) lose fertility not because their stem cells fail, but because their body's positional 'blueprint' gradually shifts out of alignment. By manipulating the molecular signals that control body polarity, …
Researchers treated female mice with fatty liver disease (MASLD) using senolytic drugs—compounds that eliminate senescent (aged) cells—and found pregnancy rates improved, particularly through reduced aging and inflammation in the ovaries. However, the treatment had limited …
The use of high-power lasers for facial rejuvenation has been growing every year. In particular, the Thulium laser in non-ablative mode has gained prominence due to its safety, postoperative comfort, and wide clinical indication. This …
Cellular senescence is an irreversible program of cell-cycle arrest that accumulates with age, contributing to chronic inflammation and various age-related diseases. A key feature of senescence paradigms is mitochondrial dysfunction, which involves not just a …
This study evaluated protein hydrolysates derived from Turkmen melon seeds (TMSPH), produced using Protamex, as bioactive components in a polyethylene (PL)-nanoclay (NC) edible nanocomposite coating for extending the shelf life of button mushrooms. Five treatments …
The physicochemical degradation of asphalt during long-term service leads to pronounced aging, characterized by increased molecular aggregation, elevated viscosity, and degraded mechanical performance. Ultrasonic treatment has shown potential for reducing the viscosity of heavy oils …
Melanoma remains a therapeutic challenge due to its aggressive nature and limited efficacy of conventional treatments. This study investigates the antimelanoma potential of Lactiplantibacillus plantarum FLPL05, a probiotic strain derived from Chinese longevity individual, using …
Ponds, ubiquitous in subtropical regions, play a pivotal role in regulating the regional hydrological cycle, fostering biodiversity, and providing livelihood opportunities. This study assesses the water quality and ecological health of ten rural and urban …
Exosomes are secreted tiny organelles that are single-membrane enclosed and can perform a broad spectrum of functions upon release, such as the reorganization of extracellular matrix and communication with other cells through the release of …
Researchers found that an ethanol extract from Salvia plebeia plant enhanced autophagy (cellular garbage disposal) and reversed senescence markers in cell culture and aged mice, with rosmarinic acid identified as a key active ingredient. The …
The internal electrocautery-assisted lid-tightening maneuver, combined with transconjunctival blepharoplasty, offers a scarless and effective approach to improve lower eyelid contour and stability, minimizing the risk of postoperative malposition.
Electric car traction batteries are typically replaced before their lifespan expires, and their widespread retirement creates a significant obstacle to resource recovery and environmental conservation. There has been a recent surge in industry interest in …
How the nucleolus recovers from acute proteostatic stress, particularly in multinucleate syncytia, remains poorly understood. In the highly polarized hyphae of the model filamentous fungus Magnaporthe oryzae, we uncover a novel stress-induced spatial quality control …
Gait variability is a critical functional indicator of dynamic balance and neurocognitive decline in health. Its translation into clinical practice is, however, challenged by a lack of age-related normative trajectories and reference values under real-world …
Researchers developed a new tool to watch autophagy (cellular recycling) in real time in naked mole-rat cells and discovered that these long-lived animals respond to stress by forming temporary vacuoles—a protective response that reverses when …
Researchers discovered that ATG-18, a protein known for triggering cellular cleanup, extends lifespan in worms through a completely different mechanism than expected. The protein interacts with a metabolic enzyme (PCK-2) to relay signals from the …