Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans
Frailty, a syndrome that decreases healthspan in older individuals, lacks effective therapies. We conducted a randomized, dose-finding clinical trial to test whether human bone marrow-derived allogeneic mesenchymal stem cells (MSCs; laromestrocel) improve physical functioning and …
BACKGROUND: Previous cross-sectional studies suggest nonlinear facial skeletal aging patterns, but longitudinal evidence quantifying acceleration of change is lacking. OBJECTIVES: The aim of the authors of this study is to quantify acceleration in facial skeletal …
Poly(L-lactic acid) (PLLA) microspheres are widely used in aesthetic and regenerative medicine to promote collagen remodeling, but their efficacy and long-term safety lack sufficient experimental data. In this study, a poly(γ-glutamic acid)-thickened PLLA microsphere formulation …
BACKGROUND: Centromere identity in eukaryotes is defined epigenetically by CENH3 (CENPA), a specialized histone H3 variant essential for kinetochore establishment and faithful chromosome segregation. However, the regulatory mechanisms governing CENH3 loading during meiosis and how …
The germinal center (GC) is a specialized structure that ensures the production of high-quality antibodies. Although recent studies have pinpointed the existence of a pre-plasma cell (prePC) population within mouse GC B cells, it remains …
Telomere biology disorders (TBDs) are characterized by bone marrow failure (BMF) and dysfunctional telomeres. So far, inherited mutations in 18 genes have been identified in TBDs. Here, we describe a child presenting with early BMF, …
Researchers tested whether an FDA-approved HIV medication (tenofovir alafenamide) could slow aging in healthy people by suppressing harmful retrotransposons. Over 12 weeks, the drug showed measurable reductions in epigenetic aging markers, but this is preliminary …
This is a protocol paper describing an upcoming clinical trial that will test whether three drugs (metformin, fisetin, and spermidine) can reduce senescent cells and reverse aging hallmarks in healthy adults over 70 within three …
Background and Objectives: Biological age, reflecting the cumulative molecular and cellular damage such as telomere attrition, epigenetic alterations and mitochondrial dysfunction, may better capture age-related decline and Alzheimer's disease (AD) risk than chronological age. Most …
BACKGROUND: Stem cells residing in the perivascular niche are critical for skeletal homeostasis. Vascular endothelin-1 (ET-1) controls stem cell fate in development, but its role in the exhaustion of skeletal stem cells (SSCs) and subsequent …
OBJECTIVE: Global growth hormone receptor knockout (GHR-/-) extends lifespan but also causes adverse effects. As a key target of growth hormone (GH), adipose tissue may mediate aging, though the underlying mechanisms remain unclear. We investigated …
Ageing biomarkers can predict mortality risk beyond chronological age. Recently, plasma proteins were used to estimate the biological ages of eleven human organs, including the brain, heart, liver, kidneys, and pancreas. Accelerated organ ageing is …
BACKGROUND: Cancer is a significant global health challenge, affecting millions of people every year. Overall survival rates have improved over time, but some patients exhibit treatment resistance, prompting ongoing research to find suitable and effective …
As people age, their immune systems weaken, which may reduce how well cancer immunotherapy works—especially in patients over 75. Researchers are testing mRNA-based approaches and senolytics (drugs that clear damaged cells) to reverse this immune …
The development of geroprotectors, compounds that slow the biological aging process, is an important goal in modern medicine. These interventions hold the promise not only of extending lifespan, but more importantly, of extending healthspan-the period …
Submandibular gland prominence can undermine aesthetic outcomes in neck and lower face rejuvenation, even after deep-plane facelifts and platysmaplasty. In selected patients, gland reduction has emerged as an effective adjunct to improve cervicomental contour. In …
Epstein-Barr virus-associated gastric cancer (EBVaGC) accounts for ~9% to 10% of gastric cancers worldwide and is defined by a distinctive molecular profile, including extreme hypermethylation of the DNA. Targeting this aberrant methylation may be a …
BACKGROUND: Autophagy genes are essential for proper uterine function, reproductive physiology, and the maintenance of endometrial atrophy (EA). OBJECTIVE: This study aims to clarify how these genes impact endometrial thickness and their significance in the …
Aging is frequently perceived negatively due to its association with the decline of various brain and bodily functions. While it is evident that motor abilities deteriorate with age, it is incorrect to assume that all …
BACKGROUND: Facial aging involves complex, region-specific changes in both soft tissue and the underlying bone. Although skeletal remodeling is believed to contribute significantly, most studies rely on cross-sectional imaging, which limits the understanding of longitudinal …